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    GUN1 s uncoupled 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817698, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GUN1
    Official Full Name
    s uncoupled 1
    Primary source
    TAIR:AT2G31400
    Locus tag
    AT2G31400
    See related
    Araport:AT2G31400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    genomes uncoupled 1; T28P16.11; T28P16_11
    Summary
    Encodes a a chloroplast-localized pentatricopeptide-repeat protein involved in regulation of nuclear gene expression.
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    Genomic context

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    See GUN1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (13386954..13390854, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene salt tolerance homologue Neighboring gene pfkB-like carbohydrate kinase family protein Neighboring gene ncRNA Neighboring gene coiled-coil protein Neighboring gene B3 domain protein (DUF313)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Retrograde Signaling by Rapid Turnover of GENOMES UNCOUPLED1. Wu GZ, et al. Plant Physiol, 2018 Mar. PMID 29367233, Free PMC Article
    2. An intracellular signal transduction pathway between the chloroplast and nucleus is involved in de-etiolation. Mochizuki N, et al. Plant Physiol, 1996 Dec. PMID 8972595, Free PMC Article
    3. The Arabidopsis plastid-signalling mutant gun1 (genomes uncoupled1) shows altered sensitivity to sucrose and abscisic acid and alterations in early seedling development. Cottage A, et al. J Exp Bot, 2010 Aug. PMID 20605896, Free PMC Article
    4. A gain-of-function mutation of plastidic invertase alters nuclear gene expression with sucrose treatment partially via GENOMES UNCOUPLED1-mediated signaling. Maruta T, et al. New Phytol, 2015 May. PMID 25628228
    5. genome uncoupled1 Mutants Are Hypersensitive to Norflurazon and Lincomycin. Zhao X, et al. Plant Physiol, 2018 Nov. PMID 30154176, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The chloroplast singlet oxygen-triggered biosynthesis of salicylic acid and jasmonic acid is mediated by EX1 and GUN1 in Arabidopsis.
      Title: The chloroplast singlet oxygen-triggered biosynthesis of salicylic acid and jasmonic acid is mediated by EX1 and GUN1 in Arabidopsis.
    2. Screening and Identification of Candidate GUN1-Interacting Proteins in Arabidopsis thaliana.
      Title: Screening and Identification of Candidate GUN1-Interacting Proteins in Arabidopsis thaliana.
    3. Identification of small non-coding RNAs responsive to GUN1 and GUN5 related retrograde signals in Arabidopsis thaliana.
      Title: Identification of small non-coding RNAs responsive to GUN1 and GUN5 related retrograde signals in Arabidopsis thaliana.
    4. Retrograde signalling in a virescent mutant triggers an anterograde delay of chloroplast biogenesis that requires GUN1 and is essential for survival.
      Title: Retrograde signalling in a virescent mutant triggers an anterograde delay of chloroplast biogenesis that requires GUN1 and is essential for survival.
    5. GUN1 influences the accumulation of NEP-dependent transcripts and chloroplast protein import in Arabidopsis cotyledons upon perturbation of chloroplast protein homeostasis.
      Title: GUN1 influences the accumulation of NEP-dependent transcripts and chloroplast protein import in Arabidopsis cotyledons upon perturbation of chloroplast protein homeostasis.
    6. Emerging from the darkness: interplay between light and plastid signaling during chloroplast biogenesis.
      Title: Emerging from the darkness: interplay between light and plastid signaling during chloroplast biogenesis.
    7. The results indicate that the COE1-GUN1 signaling pathway plays an important role in regulating the adaptation of plants to high light.
      Title: COE 1 and GUN1 regulate the adaptation of plants to high light stress.
    8. Data show that Arabidopsis proteins GUN1 and FUG1 are required for effective cold acclimation.
      Title: Relationship of GUN1 to FUG1 in chloroplast protein homeostasis.
    9. plays a direct role in RNA editing by physically interacting with MULTIPLE ORGANELLAR RNA EDITING FACTOR 2 (MORF2)
      Title: GUN1 interacts with MORF2 to regulate plastid RNA editing during retrograde signaling.
    10. The retrograde signaling protein GUN1 regulates tetrapyrrole biosynthesis.
      Title: The retrograde signaling protein GUN1 regulates tetrapyrrole biosynthesis.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    General gene information

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    Homology

    NM_001336330.1
    NM_128697.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloroplast-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondria-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    s uncoupled 1
    NP_180698.1
    • genomes uncoupled 1 (GUN1); CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885), Smr protein/MutS2 C-terminal (InterPro:IPR002625); BEST Arabidopsis thaliana protein match is: plastid transcriptionally active 2 (TAIR:AT1G74850.1); Has 66090 Blast hits to 15992 proteins in 322 species: Archae - 5; Bacteria - 98; Metazoa - 1298; Fungi - 977; Plants - 60012; Viruses - 1; Other Eukaryotes - 3699 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13386954..13390854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128697.3 → NP_180698.1  s uncoupled 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIC9
      UniProtKB/TrEMBL
      A0A178VTQ5, A0A5S9X2Y1, A0A654EZ94
      Conserved Domains (3) summary
      smart00463
      Location:781 → 872
      SMR; Small MutS-related domain
      PLN03218
      Location:277 → 702
      PLN03218; maturation of RBCL 1; Provisional
      sd00004
      Location:411 → 438
      PPR; PPR repeat [structural motif]

    2. NM_001336330.1 → NP_001324971.1  s uncoupled 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VTQ5, A0A1P8B1Q9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIC9.1

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