U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PP2A-1 protein phosphatase 2A-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842276, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PP2A-1
    Official Full Name
    protein phosphatase 2A-2
    Primary source
    TAIR:AT1G59830
    Locus tag
    AT1G59830
    See related
    Araport:AT1G59830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F23H11.15; F23H11_15; protein phosphatase 2A-1; protein phosphatase 2A-2
    Summary
    Encodes one of the isoforms of the catalytic subunit of protein phosphatase 2A: AT1G59830/PP2A-1, AT1G10430/PP2A-2, At2g42500/PP2A-3, At3g58500/PP2A-4 [Plant Molecular Biology (1993) 21:475-485 and (1994) 26:523-528; Note that in more recent publications, there is mixed use of gene names for PP2A-3 and PP2A-4 - some refer to At2g42500 as PP2A-3 and some as PP2A-4].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PP2A-1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (22020377..22022503, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AGAMOUS-like 50 Neighboring gene aminophospholipid ATPase 3 Neighboring gene Defensin-like (DEFL) family protein Neighboring gene DNA-directed RNA polymerase II subunit RPB1-like protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction. Robles LM, et al. J Exp Bot, 2007. PMID 17526916
    2. Enhanced ethylene responsiveness in the Arabidopsis eer1 mutant results from a loss-of-function mutation in the protein phosphatase 2A A regulatory subunit, RCN1. Larsen PB, et al. Plant J, 2003 Jun. PMID 12787251
    3. Protein phosphatases in higher plants: multiplicity of type 2A phosphatases in Arabidopsis thaliana. Ariño J, et al. Plant Mol Biol, 1993 Feb. PMID 8382968
    4. Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Tran HT, et al. Plant J, 2012 Jul. PMID 22404109
    5. TAP46 plays a positive role in the ABSCISIC ACID INSENSITIVE5-regulated gene expression in Arabidopsis. Hu R, et al. Plant Physiol, 2014 Feb. PMID 24357600, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_104676.5
    NM_202321.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein phosphatase 2A-2
    NP_176192.1
    • protein phosphatase 2A-2 (PP2A-1); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-2 (TAIR:AT1G10430.1); Has 6770 Blast hits to 6587 proteins in 473 species: Archae - 80; Bacteria - 185; Metazoa - 2396; Fungi - 1410; Plants - 968; Viruses - 5; Other Eukaryotes - 1726 (source: NCBI BLink).
    NP_974050.1
    • protein phosphatase 2A-2 (PP2A-1); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-2 (TAIR:AT1G10430.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22020377..22022503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104676.5 → NP_176192.1  protein phosphatase 2A-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07099, Q3ECM1
      UniProtKB/TrEMBL
      A0A654EK18, A0A7G2E239
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    2. NM_202321.2 → NP_974050.1  protein phosphatase 2A-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E239
      Conserved Domains (2) summary
      cd07415
      Location:6 → 257
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      pfam00149
      Location:48 → 242
      Metallophos; Calcineurin-like phosphoesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07099.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools