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    PS2 inorganic pyrophosphatase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843632, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PS2
    Official Full Name
    inorganic pyrophosphatase 1
    Primary source
    TAIR:AT1G73010
    Locus tag
    AT1G73010
    See related
    Araport:AT1G73010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPPsPase1; ATPS2; F3N23.21; F3N23_21; phosphate starvation-induced gene 2; PPsPase1; pyrophosphate-specific phosphatase1
    Summary
    Encodes PPsPase1, a pyrophosphate-specific phosphatase catalyzing the specific cleavage of pyrophosphate (Km 38.8 uM) with an alkaline catalytic pH optimum. Expression is upregulated in the shoot of cax1/cax3 mutant.
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    Genomic context

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    See PS2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (27464528..27466348, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene beta-galactosidase 17 Neighboring gene PYR1-like 3 Neighboring gene anoctamin-like protein Neighboring gene ncRNA Neighboring gene SNF7 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of type II H(+)-PPases and PPsPase1/PECP2 in early developmental stages and PPi homeostasis of Arabidopsis thaliana. Tojo H, et al. Front Plant Sci, 2023. PMID 36778688, Free PMC Article
    2. The Arabidopsis thaliana phosphate starvation responsive gene AtPPsPase1 encodes a novel type of inorganic pyrophosphatase. May A, et al. Biochim Biophys Acta, 2011 Feb. PMID 21122813
    3. The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content. Hanchi M, et al. Plant Physiol, 2018 Apr. PMID 29475899, Free PMC Article
    4. Arabidopsis PECP1 and PS2 are phosphate starvation-inducible phosphocholine phosphatases. Angkawijaya AE, et al. Biochem Biophys Res Commun, 2017 Dec 9. PMID 28942147
    5. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that pyrophosphate-specific phosphatase1 (PPsPase1) and phosphoethanolamine/phosphocholine phosphatase 1 (PECP1) do not influence phosphate homeostasis.
      Title: The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content.
    2. Arabidopsis PECP1 and PS2 are phosphate starvation-inducible phosphocholine phosphatases.
      Title: Arabidopsis PECP1 and PS2 are phosphate starvation-inducible phosphocholine phosphatases.
    3. Data show that the tight control of AtPPsPase1 gene expression underlines its important role in the Pi starvation response and suggests that cleavage of pyrophosphate is an immediate metabolic adaptation reaction.
      Title: The Arabidopsis thaliana phosphate starvation responsive gene AtPPsPase1 encodes a novel type of inorganic pyrophosphatase.
    Submit: New GeneRIF Correction

    General gene information

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    NM_105959.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    involved_in cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein tetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    inorganic pyrophosphatase 1
    NP_565052.1
    • phosphate starvation-induced gene 2 (PS2); FUNCTIONS IN: phosphatase activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate phosphatase, PHOSPHO2 (InterPro:IPR016965), HAD-superfamily hydrolase, subfamily IB, PSPase-like (InterPro:IPR006383), Pyridoxal phosphate phosphatase-related (InterPro:IPR006384); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate phosphatase-related protein (TAIR:AT1G17710.1); Has 357 Blast hits to 345 proteins in 104 species: Archae - 0; Bacteria - 14; Metazoa - 174; Fungi - 18; Plants - 106; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27464528..27466348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105959.3 → NP_565052.1  inorganic pyrophosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67YC0, Q8LDK9, Q9SSM6
      UniProtKB/TrEMBL
      A0A654ETL8
      Conserved Domains (2) summary
      pfam00702
      Location:15 → 200
      Hydrolase; haloacid dehalogenase-like hydrolase
      pfam06888
      Location:14 → 246
      Put_Phosphatase; Putative Phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q67YC0.1

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