DL3 dynamin-like 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DL3
Official Full Name: dynamin-like 3
Primary source: TAIR:AT1G59610
Locus tag: AT1G59610
See related: Araport:AT1G59610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ADL3; CF1; DRP2B; Dynamin related protein 2B; dynamin-like 3; DYNAMIN-LIKE 3; T30E16.17; T30E16_17
Summary: A high molecular weight GTPase whose GTP-binding domain shows a low homology to those of other plant dynamin-like proteins.Contains a pleckstrin homologous domain. DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis.
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Genomic context

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See DL3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 22

Sequence:: Chromosome: 1; NC_003070.9 (21893142..21901086)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, AVR3a associates with the Dynamin-Related Protein 2 (DRP2), a plant GTPase implicated in receptor-mediated endocytosis. [DRP2B]
Title: Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2.
this study adds DRP2B to the relatively short list of known vesicular trafficking proteins with roles in flg22-signaling and PTI in plants.
Title: Loss of Arabidopsis thaliana Dynamin-Related Protein 2B reveals separation of innate immune signaling pathways.
DRP2A and DRP2B function coordinately in multiple pathways of post-Golgi trafficking in phosphatidylinositol 3- or 4-kinase and cytoskeleton polymerization-dependent manners
Title: Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking.
Data support a role for DRP2A/B in endocytosis and demonstrate that the function of at least one of these closely related proteins is essential for plant growth.
Title: A role for Arabidopsis dynamin related proteins DRP2A/B in endocytosis; DRP2 function is essential for plant growth.
drp2ab double mutants undergo an early developmental arrest prior to the first mitotic cell division during both male and female gametophytic development, resulting in gametophytic lethality.
Title: The Arabidopsis dynamin-related protein2 family is essential for gametophyte development.
DRP2B shares domain organization with animal dynamins whereas DRP1A is plant-specific.
Title: Arabidopsis dynamin-related proteins DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis.
Arabidopsis dynamin-related proteins, DRP1A and DRP2B, from two different families, participate in membrane remodeling at a similar place in the cell plate. [DRP2B]
Title: Arabidopsis dynamin-related protein DRP2B is co-localized with DRP1A on the leading edge of the forming cell plate.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104654.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair initiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell plate	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: dynamin-like 3

NP_176170.1

dynamin-like 3 (DL3); FUNCTIONS IN: protein binding, clathrin binding, GTPase activity; INVOLVED IN: synaptic vesicle endocytosis; LOCATED IN: clathrin-coated endocytic vesicle, plasma membrane, vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Pleckstrin homology-type (InterPro:IPR011993), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: dynamin-like protein 6 (TAIR:AT1G10290.1); Has 3314 Blast hits to 3127 proteins in 342 species: Archae - 0; Bacteria - 101; Metazoa - 1476; Fungi - 678; Plants - 726; Viruses - 0; Other Eukaryotes - 333 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

21893142..21901086

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104654.5 → NP_176170.1 dynamin-like 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176170.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LQ55, Q9SLT3, Q9SLT4, Q9SXX3

UniProtKB/TrEMBL

A0A5S9WQM5, A0A654EJE7, G1JSJ5

Conserved Domains (4) summary

cd08771
Location:41 → 303

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

smart00233
Location:584 → 703

PH; Pleckstrin homology domain

pfam01031
Location:371 → 494

Dynamin_M; Dynamin central region

cl02558
Location:744 → 817

GED; Dynamin GTPase effector domain