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    RHD1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842752, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RHD1
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT1G64440
    Locus tag
    AT1G64440
    See related
    Araport:AT1G64440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F15H21.11; F15H21_11; REB1; ROOT EPIDERMAL BULGER1; ROOT HAIR DEFECTIVE 1; UDP-GLUCOSE 4-EPIMERASE; UGE4
    Summary
    Encodes a protein with UDP-D-glucose 4-epimerase activity. Mutants in RHD1 have abnormally shaped root hairs with a bulbous region at the base. Allelic to REB1 encoding a UDP-D-glucose 4-epimerase involved in cell wall biosynthesis.Involved in growth and cell wall carbohydrate biosynthesis.
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    Genomic context

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    See RHD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (23936975..23939899)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Glycine-rich protein family Neighboring gene collagen triple helix protein Neighboring gene phosphatidylinositol 4-kinase gamma-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UDP-D-galactose synthesis by UDP-glucose 4-epimerase 4 is required for organization of the trans-Golgi network/early endosome in Arabidopsis thaliana root epidermal cells. Wang S, et al. J Plant Res, 2015 Sep. PMID 26013532
    2. The reb1-1 mutation of Arabidopsis. Effect on the structure and localization of galactose-containing cell wall polysaccharides. Nguema-Ona E, et al. Plant Physiol, 2006 Apr. PMID 16500990, Free PMC Article
    3. Mutation of a UDP-glucose-4-epimerase alters nematode susceptibility and ethylene responses in Arabidopsis roots. Wubben MJ 2nd, et al. Plant J, 2004 Dec. PMID 15546354
    4. Galactose biosynthesis in Arabidopsis: genetic evidence for substrate channeling from UDP-D-galactose into cell wall polymers. Seifert GJ, et al. Curr Biol, 2002 Oct 29. PMID 12419184
    5. Identification and characterization of an Arabidopsis mutant with altered localization of NIP5;1, a plasma membrane boric acid channel, reveals the requirement for D-galactose in endomembrane organization. Uehara M, et al. Plant Cell Physiol, 2014 Apr. PMID 24343997

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This data from this study indicate the importance of UDP-D-galactose synthesis by UGE4 for the organization and function of endomembranes, especially TGN/EEs, which are a sorting station of the secretory and vacuolar pathways.
      Title: UDP-D-galactose synthesis by UDP-glucose 4-epimerase 4 is required for organization of the trans-Golgi network/early endosome in Arabidopsis thaliana root epidermal cells.
    2. Rough mapping and whole-genome sequencing identified the mutant with altered localization of NIP5;1 as an allele of UDP-glucose 4-epimerase 4.
      Title: Identification and characterization of an Arabidopsis mutant with altered localization of NIP5;1, a plasma membrane boric acid channel, reveals the requirement for D-galactose in endomembrane organization.
    3. UGE2 and UGE4 influence growth and cell wall carbohydrate biosynthesis throughout the plant, UGE3 is specialized for pollen development, and UGE1 and UGE5 might act in stress situations.
      Title: UDP-glucose 4-epimerase isoforms UGE2 and UGE4 cooperate in providing UDP-galactose for cell wall biosynthesis and growth of Arabidopsis thaliana.
    4. RHD1, a UDP-glucose-4-epimerase, is a likely target of root-specific negative regulation by ethylene and that loss of RHD1 function results in a heightened sensitivity of root tissues to both ethylene and auxin. [RHD1]
      Title: Mutation of a UDP-glucose-4-epimerase alters nematode susceptibility and ethylene responses in Arabidopsis roots.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_105119.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-glucose 4-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 4-epimerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables UDP-glucose 4-epimerase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plant-type cell wall biogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in rhamnogalacturonan I biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in rhamnogalacturonan II biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xyloglucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_176625.1
    • ROOT HAIR DEFECTIVE 1 (RHD1); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose 4-epimerase (InterPro:IPR005886); BEST Arabidopsis thaliana protein match is: UDP-D-glucose/UDP-D-galactose 4-epimerase 5 (TAIR:AT4G10960.1); Has 39875 Blast hits to 39850 proteins in 2971 species: Archae - 802; Bacteria - 24274; Metazoa - 636; Fungi - 515; Plants - 1061; Viruses - 41; Other Eukaryotes - 12546 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23936975..23939899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105119.5 → NP_176625.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C7W7, Q9SGX0
      UniProtKB/TrEMBL
      A0A178W7Z8, A0A5S9WS12, A0A7G2E6C8
      Conserved Domains (1) summary
      PLN02240
      Location:1 → 348
      PLN02240; UDP-glucose 4-epimerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C7W7.1

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