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    VPS41 vacuolar protein sorting 41 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837340, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VPS41
    Official Full Name
    vacuolar protein sorting 41
    Primary source
    TAIR:AT1G08190
    Locus tag
    AT1G08190
    See related
    Araport:AT1G08190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVAM2; ATVPS41; T23G18.5; T23G18_5; vacuolar protein sorting 41; VACUOLAR PROTEIN SORTING 41; VAM2; ZIGZAG SUPPRESSOR 2; ZIP2
    Summary
    Might be involved in protein sorting to the vacuole.
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    Genomic context

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    See VPS41 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (2567420..2573448)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Histone superfamily protein Neighboring gene cyclin-dependent kinase inhibitor Neighboring gene UDP-D-apiose/UDP-D-xylose synthase 2 Neighboring gene Eukaryotic aspartyl protease family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth. Jiang D, et al. Plant Physiol, 2022 Jun 27. PMID 35417008, Free PMC Article
    2. Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants. Brillada C, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104351, Free PMC Article
    3. ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles. Niihama M, et al. Plant Cell Physiol, 2009 Dec. PMID 19884248
    4. Distinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis. Takemoto K, et al. Proc Natl Acad Sci U S A, 2018 Mar 6. PMID 29463724, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth.
      Title: Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth.
    2. evidence for genetic interactions between VPS41 and VTI11 SNARE that regulate vacuole fusion, and the requirement of a functional SNARE complex for normal VPS41 and VPS33 localization.
      Title: Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants.
    3. AtVPS41 is involved in protein trafficking to the vacuole.
      Title: ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100693.4

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in endosomal vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to vacuole TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 41
    NP_172297.2
    • vacuolar protein sorting 41 (VPS41); FUNCTIONS IN: binding, nucleotide binding, zinc ion binding; INVOLVED IN: gravitropism, protein targeting to vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Zinc finger, RING-type (InterPro:IPR001841), WD40 repeat (InterPro:IPR001680), Vacuolar protein sorting-associated protein 41 (InterPro:IPR016902), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), Armadillo-type fold (InterPro:IPR016024), WD40 repeat, subgroup (InterPro:IPR019781), Clathrin, heavy chain/VPS, 7-fold repeat (InterPro:IPR000547); Has 13288 Blast hits to 4251 proteins in 360 species: Archae - 4; Bacteria - 340; Metazoa - 7814; Fungi - 1141; Plants - 584; Viruses - 346; Other Eukaryotes - 3059 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2567420..2573448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100693.4 → NP_172297.2  vacuolar protein sorting 41 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172297.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93043, Q9SGE1
      UniProtKB/TrEMBL
      A0A178W6H2
      Conserved Domains (4) summary
      smart00299
      Location:613 → 765
      CLH; Clathrin heavy chain repeat homology
      sd00039
      Location:63 → 96
      7WD40; WD40 repeat [structural motif]
      cd16484
      Location:887 → 922
      RING-H2_Vps; RING finger, H2 subclass, found in vacuolar protein sorting-associated proteins Vps8, Vps11, Vps18, Vps41, and similar proteins
      cl29593
      Location:62 → 217
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93043.3

    Gene LinkOut

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