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    ACOS5 acyl-CoA synthetase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842596, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACOS5
    Official Full Name
    acyl-CoA synthetase 5
    Primary source
    TAIR:AT1G62940
    Locus tag
    AT1G62940
    See related
    Araport:AT1G62940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acyl-CoA synthetase 5; F16P17.9; F16P17_9
    Summary
    encodes an acyl-CoA synthetase, has in vitro activity towards medium- to long-chain fatty acids and their hydroxylated derivatives. Expressed in the tapetum. Involved in pollen wall exine formation. Null mutants were devoid of pollen grains at anther maturity and were completely male sterile.
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    Genomic context

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    See ACOS5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (23310532..23312795)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene leucine-rich repeat transmembrane protein kinase family protein Neighboring gene ACC synthase 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana. Morita H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Mar 1. PMID 21393854, Free PMC Article
    2. A novel fatty Acyl-CoA Synthetase is required for pollen development and sporopollenin biosynthesis in Arabidopsis. de Azevedo Souza C, et al. Plant Cell, 2009 Feb. PMID 19218397, Free PMC Article
    3. Sporopollenin biosynthetic enzymes interact and constitute a metabolon localized to the endoplasmic reticulum of tapetum cells. Lallemand B, et al. Plant Physiol, 2013 Jun. PMID 23632852, Free PMC Article
    4. Slowing development restores the fertility of thermo-sensitive male-sterile plant lines. Zhu J, et al. Nat Plants, 2020 Apr. PMID 32231254
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the crystallization and X-ray analysis of Arabidopsis thaliana 4-coumarate:CoA ligase.
      Title: Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana.
    2. ACOS5 encodes an enzyme that participates in a conserved and ancient biochemical pathway required for sporopollenin monomer biosynthesis.
      Title: A novel fatty Acyl-CoA Synthetase is required for pollen development and sporopollenin biosynthesis in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_104972.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 4-coumarate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-coumarate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables medium-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty-acyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen exine formation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within sporopollenin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sporopollenin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-CoA synthetase 5
    NP_176482.1
    • acyl-CoA synthetase 5 (ACOS5); CONTAINS InterPro DOMAIN/s: AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 80303 Blast hits to 72777 proteins in 3663 species: Archae - 1209; Bacteria - 52830; Metazoa - 3472; Fungi - 4003; Plants - 2782; Viruses - 1; Other Eukaryotes - 16006 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23310532..23312795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104972.3 → NP_176482.1  acyl-CoA synthetase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LQ12
      UniProtKB/TrEMBL
      A0A178W5B9, A0A5S9WP31, A0A654EW74
      Conserved Domains (1) summary
      PLN02330
      Location:1 → 542
      PLN02330; 4-coumarate--CoA ligase-like 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQ12.1

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