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    PCNA1 proliferating cellular nuclear antigen 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837249, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PCNA1
    Official Full Name
    proliferating cellular nuclear antigen 1
    Primary source
    TAIR:AT1G07370
    Locus tag
    AT1G07370
    See related
    Araport:AT1G07370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPCNA1; F22G5.29; F22G5_29; PROLIFERATING CELLULAR NUCLEAR ANTIGEN; proliferating cellular nuclear antigen 1; PROLIFERATING CELLULAR NUCLEAR ANTIGEN 1
    Summary
    Encodes putative proliferating cell nuclear antigen involved in cell cycle regulation. May be sumoylated.
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    Genomic context

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    See PCNA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (2263037..2264553)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein Neighboring gene Neutral/alkaline non-lysosomal ceramidase Neighboring gene receptor like protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites. Strzalka W, et al. J Exp Bot, 2012 May. PMID 22330895
    2. Arabidopsis thaliana: proliferating cell nuclear antigen 1 and 2 possibly form homo- and hetero-trimeric complexes in the plant cell. Strzalka W, et al. Plant Signal Behav, 2013 Jul. PMID 23656863, Free PMC Article
    3. Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect. Xue C, et al. DNA Repair (Amst), 2015 Apr. PMID 25728088
    4. Internal telomeric repeats and 'TCP domain' protein-binding sites co-operate to regulate gene expression in Arabidopsis thaliana cycling cells. Trémousaygue D, et al. Plant J, 2003 Mar. PMID 12631321
    5. Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis. Raynaud C, et al. Plant J, 2006 Aug. PMID 16771839

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis PCNA1 and PCNA2 differ in their efficiency for ubiquitination and sumoylation, leading to their differential responses to DNA damage in yeast cells.
      Title: Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect.
    2. PCNA1 and PCNA2 may cooperate in planta by forming homo- and heterotrimeric rings.
      Title: Arabidopsis thaliana: proliferating cell nuclear antigen 1 and 2 possibly form homo- and hetero-trimeric complexes in the plant cell.
    3. Ubiquitin-conjugating enzymes and RAD5a proteins are involved in the ubiquitination of plant PCNA at lysine 164.
      Title: RAD5a ubiquitin ligase is involved in ubiquitination of Arabidopsis thaliana proliferating cell nuclear antigen.
    4. These results clearly show that plant PCNA is post-translationally modified in bacteria and may be sumoylated in a plant cell at various sites.
      Title: Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites.
    5. atomic resolution crystal structures of the PCNA1 and PCNA2 complexed with the C-terminal segment of human p21; structures demonstrated that PCNA1 & 2 adopt identical architectures
      Title: Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100611.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA polymerase processivity factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    proliferating cellular nuclear antigen 1
    NP_172217.1
    • proliferating cellular nuclear antigen 1 (PCNA1); CONTAINS InterPro DOMAIN/s: Proliferating cell nuclear antigen, PCNA (InterPro:IPR000730), Proliferating cell nuclear antigen, PCNA, C-terminal (InterPro:IPR022649), Proliferating cell nuclear antigen, PCNA, conserved site (InterPro:IPR022659), Proliferating cell nuclear antigen, PCNA, N-terminal (InterPro:IPR022648); BEST Arabidopsis thaliana protein match is: proliferating cell nuclear antigen 2 (TAIR:AT2G29570.1); Has 1857 Blast hits to 1845 proteins in 456 species: Archae - 391; Bacteria - 0; Metazoa - 315; Fungi - 169; Plants - 159; Viruses - 71; Other Eukaryotes - 752 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2263037..2264553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100611.4 → NP_172217.1  proliferating cellular nuclear antigen 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7UIK5, Q9LNV6, Q9M7Q7
      UniProtKB/TrEMBL
      A0A178W9N0, A0A5S9T434, A0A6B7JDQ1
      Conserved Domains (1) summary
      PLN00057
      Location:1 → 263
      PLN00057; proliferating cell nuclear antigen; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M7Q7.2

    Gene LinkOut

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