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    SKP2A F-box/RNI-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838740, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SKP2A
    Official Full Name
    F-box/RNI-like superfamily protein
    Primary source
    TAIR:AT1G21410
    Locus tag
    AT1G21410
    See related
    Araport:AT1G21410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24J8.5; F24J8_5
    Summary
    AtSKP2;1 is a homolog of human SKP2, the human F-box protein that recruits E2F1. Contains an F-box motif at the N-terminal region and a C-terminal Leu-rich repeat domain. Forms part of an E3-ubiquitin-ligase SCF (Skp1, cullin, F-box) complex and recruits phosphorylated AtE2Fc, a transcriptional factor that might play a role in cell division and during the transition from skotomorphogenesis to photomorphogenesis. AtSKP2;1 (At1g21410) and AtSKP2;2 (At1g77000) may be duplicated genes.
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    Genomic context

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    See SKP2A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (7496998..7499616)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene thiamine diphosphate-binding fold (THDP-binding) superfamily protein Neighboring gene tRNA-Gln Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene Phosphoenolpyruvate carboxylase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SKP2A protein, an F-box that regulates cell division, is degraded via the ubiquitin pathway. Jurado S, et al. Plant Signal Behav, 2008 Oct. PMID 19704565, Free PMC Article
    2. The Arabidopsis cell cycle F-box protein SKP2A binds to auxin. Jurado S, et al. Plant Cell, 2010 Dec. PMID 21139066, Free PMC Article
    3. The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis. del Pozo JC, et al. Plant Cell, 2006 Sep. PMID 16920782, Free PMC Article
    4. SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway. Jurado S, et al. Plant J, 2008 Mar. PMID 18036202
    5. Arabidopsis E2Fc functions in cell division and is degraded by the ubiquitin-SCF(AtSKP2) pathway in response to light. del Pozo JC, et al. Plant Cell, 2002 Dec. PMID 12468727, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data indicate that SKP2A is an auxin binding protein that connects auxin signaling with cell division
      Title: The Arabidopsis cell cycle F-box protein SKP2A binds to auxin.
    2. SKP2A is a positive regulator of cell division, and its stability is controlled by auxin-dependent degradation. [SKP2A]
      Title: SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332504.1
    NM_101993.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cellular response to auxin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    F-box/RNI-like superfamily protein
    NP_564139.1
    • SKP2A; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364), Leucine-rich repeat, cysteine-containing subtype (InterPro:IPR006553); BEST Arabidopsis thaliana protein match is: RNI-like superfamily protein (TAIR:AT1G77000.2); Has 8874 Blast hits to 3879 proteins in 263 species: Archae - 0; Bacteria - 386; Metazoa - 3510; Fungi - 1080; Plants - 2969; Viruses - 9; Other Eukaryotes - 920 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7496998..7499616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101993.4 → NP_564139.1  F-box/RNI-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDN3, Q9LPL4
      UniProtKB/TrEMBL
      A0A178W530, A0A5S9VFF7
      Conserved Domains (3) summary
      cd09293
      Location:115 → 264
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:66 → 91
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:28 → 63
      F-box-like

    2. NM_001332504.1 → NP_001321134.1  F-box/RNI-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDN3, Q9LPL4
      UniProtKB/TrEMBL
      A0A178W530, A0A5S9VFF7
      Conserved Domains (3) summary
      cd09293
      Location:115 → 264
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:66 → 91
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:28 → 63
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LPL4.1

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