GRF2 general regulatory factor 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GRF2
Official Full Name: general regulatory factor 2
Primary source: TAIR:AT1G78300
Locus tag: AT1G78300
See related: Araport:AT1G78300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 14-3-3 PROTEIN G-BOX FACTOR14 OMEGA; 14-3-3OMEGA; F3F9.16; F3F9_16; general regulatory factor 2; GF14 OMEGA
Summary: G-box binding factor GF14 omega encoding a 14-3-3 protein
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Genomic context

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See GRF2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (29461391..29463389)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

14-3-3epsilon and 14-3-3omega isoforms, which were representative of epsilon and non-epsilon phylogenetic groups, were overexpressed in Arabidopsis thaliana plants. H(+)-ATPase activity was increased in 14-3-3omega-overexpressing plants, whereas overexpression of both 14-3-3 isoforms brought about cold stress tolerance.
Title: Overexpression of 14-3-3 proteins enhances cold tolerance and increases levels of stress-responsive proteins of Arabidopsis plants.
14-3-3 proteins, in conjunction with specific divalent cations, may stimulate TMKP1 activity.
Title: Regulation of the wheat MAP kinase phosphatase 1 by 14-3-3 proteins.
the phosphorylation status of Ser-62 can regulate the binding of 14-3-3omega to target proteins, suggesting that Ser-62 might be a conserved key element to modulate target binding in both plants and animals.
Title: Phosphomimetic mutation of a conserved serine residue in Arabidopsis thaliana 14-3-3ω suggests a regulatory role of phosphorylation in dimerization and target interactions.
To our knowledge, NR is the first enzyme that harbors two independent 14-3-3 binding sites with different affinities, which both need to be occupied by 14-3-3omega to confer full inhibition of NR activity under physiological conditions.
Title: Dual binding of 14-3-3 protein regulates Arabidopsis nitrate reductase activity.
cuc1 grf1/2/3, cuc2 grf1/2/3, and cuc3 grf1/2/3 quadruple mutants showed dramatic increases in cotyledon fusion as well as floral organ fusion.
Title: Genetic interaction between GROWTH-REGULATING FACTOR and CUP-SHAPED COTYLEDON in organ separation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_106479.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphorylated amino acid binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: general regulatory factor 2

NP_565176.1

general regulatory factor 2 (GRF2); FUNCTIONS IN: protein phosphorylated amino acid binding; INVOLVED IN: brassinosteroid mediated signaling pathway; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: GF14 protein phi chain (TAIR:AT1G35160.1); Has 2698 Blast hits to 2688 proteins in 383 species: Archae - 0; Bacteria - 0; Metazoa - 1259; Fungi - 318; Plants - 766; Viruses - 0; Other Eukaryotes - 355 (source: NCBI BLink).