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    GLX2-1 glyoxalase 2-1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818944, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLX2-1
    Official Full Name
    glyoxalase 2-1
    Primary source
    TAIR:AT2G43430
    Locus tag
    AT2G43430
    See related
    Araport:AT2G43430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GLY1; glyoxalase 2-1; GLYOXALASE II; T1O24.17
    Summary
    Encodes a predicted mitochondrial glyoxalase GLX2-1. Studies using recombinant protein show that GLX2-1 contains a dinuclear metal binding site, but does not have glyoxalase 2 activity.
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    Genomic context

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    See GLX2-1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (18035349..18038334, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA binding protein Neighboring gene 3-beta hydroxysteroid dehydrogenase/isomerase family protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana glyoxalase 2-1 is required during abiotic stress but is not essential under normal plant growth. Devanathan S, et al. PLoS One, 2014. PMID 24760003, Free PMC Article
    2. Arabidopsis thaliana mitochondrial glyoxalase 2-1 exhibits beta-lactamase activity. Limphong P, et al. Biochemistry, 2009 Sep 15. PMID 19735113, Free PMC Article
    3. Arabidopsis thaliana GLX2-1 contains a dinuclear metal binding site, but is not a glyoxalase 2. Limphong P, et al. Biochem J, 2009 Jan 1. PMID 18782082, Free PMC Article
    4. Molecular characterization of glyoxalase II from Arabidopsis thaliana. Maiti MK, et al. Plant Mol Biol, 1997 Nov. PMID 9349270
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that Arabidopsis thaliana GLX2-1 is not essential during normal plant life, but is required during specific stress conditions.
      Title: Arabidopsis thaliana glyoxalase 2-1 is required during abiotic stress but is not essential under normal plant growth.
    2. Glx2-1 can hydrolyze cephalosporins and carbapenems, albeit with rate constants slower than those of most metallo-beta-lactamases.
      Title: Arabidopsis thaliana mitochondrial glyoxalase 2-1 exhibits beta-lactamase activity.
    3. Results demonstrate that Arabidopsis GLX2-1 is a novel member of the metallo-beta-lactamase superfamily that contains a dinuclear metal binding site.
      Title: Arabidopsis thaliana GLX2-1 contains a dinuclear metal binding site, but is not a glyoxalase 2.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001337029.1
    NM_129904.3
    NM_201950.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-lactamase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-lactamase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to amino acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to anoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    glyoxalase 2-1
    NP_565999.1
    • glyoxalase 2-1 (GLX2-1); CONTAINS InterPro DOMAIN/s: Beta-lactamase, class B, conserved site (InterPro:IPR001018), Beta-lactamase-like (InterPro:IPR001279), Hydroxyacylglutathione hydrolase (InterPro:IPR017782); BEST Arabidopsis thaliana protein match is: glyoxalase 2-4 (TAIR:AT1G06130.2); Has 15540 Blast hits to 15539 proteins in 2481 species: Archae - 339; Bacteria - 10160; Metazoa - 480; Fungi - 326; Plants - 230; Viruses - 0; Other Eukaryotes - 4005 (source: NCBI BLink).
    NP_973679.1
    • glyoxalase 2-1 (GLX2-1); CONTAINS InterPro DOMAIN/s: Beta-lactamase, class B, conserved site (InterPro:IPR001018), Beta-lactamase-like (InterPro:IPR001279), Hydroxyacylglutathione hydrolase (InterPro:IPR017782); BEST Arabidopsis thaliana protein match is: glyoxalase 2-4 (TAIR:AT1G06130.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18035349..18038334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129904.3 → NP_565999.1  glyoxalase 2-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22857, O24494, O24495
      UniProtKB/TrEMBL
      A0A5S9X6M7, A0A654F2V9
      Conserved Domains (1) summary
      PLN02398
      Location:1 → 331
      PLN02398; hydroxyacylglutathione hydrolase

    2. NM_201950.3 → NP_973679.1  glyoxalase 2-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X6M7, F4IR49
      Conserved Domains (3) summary
      PLN02398
      Location:1 → 313
      PLN02398; hydroxyacylglutathione hydrolase
      pfam16123
      Location:229 → 312
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:65 → 227
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    3. NM_001337029.1 → NP_001323646.1  glyoxalase 2-1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWG4, A0A1P8AXM9, A0A384LBX4, A0A5S9X6M7
      Conserved Domains (1) summary
      PLN02398
      Location:1 → 286
      PLN02398; hydroxyacylglutathione hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O24495.2

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