PIN1 Auxin efflux carrier family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PIN1
Official Full Name: Auxin efflux carrier family protein
Primary source: TAIR:AT1G73590
Locus tag: AT1G73590
See related: Araport:AT1G73590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PIN-FORMED 1; ATPIN1; F6D5.2; F6D5_2; PIN-FORMED 1
Summary: Encodes an auxin efflux carrier involved in shoot and root development. It is involved in the maintenance of embryonic auxin gradients. Loss of function severely affects organ initiation, pin1 mutants are characterised by an inflorescence meristem that does not initiate any flowers, resulting in the formation of a naked inflorescence stem. PIN1 is involved in the determination of leaf shape by actively promoting development of leaf margin serrations. In roots, the protein mainly resides at the basal end of the vascular cells, but weak signals can be detected in the epidermis and the cortex. Expression levels and polarity of this auxin efflux carrier change during primordium development suggesting that cycles of auxin build-up and depletion accompany, and may direct, different stages of primordium development. PIN1 action on plant development does not strictly require function of PGP1 and PGP19 proteins.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PIN1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (27659673..27663253)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response.
Title: AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response.
Structural insights into auxin recognition and efflux by Arabidopsis PIN1.
Title: Structural insights into auxin recognition and efflux by Arabidopsis PIN1.
The Arabidopsis STE20/Hippo kinase SIK1 regulates polarity independently of PIN proteins.
Title: The Arabidopsis STE20/Hippo kinase SIK1 regulates polarity independently of PIN proteins.
HSP90 affects root growth in Arabidopsis by regulating the polar distribution of PIN1.
Title: HSP90 affects root growth in Arabidopsis by regulating the polar distribution of PIN1.
Asynchrony of ovule primordia initiation in Arabidopsis.
Title: Asynchrony of ovule primordia initiation in Arabidopsis.
IBR5 is essential for the establishment of PIN-FORMED 1 (PIN1)-directed auxin maxima at the tips of leaf serration, which is vital for the elaborated regulation during its formation.
Title: IBR5 Regulates Leaf Serrations Development via Modulation of the Expression of PIN1.
FL genes act redundantly with FKD1 in the secretory pathway to establish appropriate PIN1 localization in provascular tissue.
Title: Members of the Arabidopsis FORKED1-LIKE gene family act to localize PIN1 in developing veins.
Higher order patellin mutants display reduced PIN1 repolarization in response to auxin, shorter root apical meristem, and drastic defects in embryo and seedling development.
Title: PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in Arabidopsis thaliana.
regardless of the functionality of PIN1-mediated polar auxin transport, auxin is present in the shoot apical meristem and vascular strands.
Title: Ontogenetic Changes in Auxin Biosynthesis and Distribution Determine the Organogenic Activity of the Shoot Apical Meristem in pin1 Mutants.
Light triggers PIN1 polar membrane localization.
Title: Converging Light, Energy and Hormonal Signaling Control Meristem Activity, Leaf Initiation, and Growth.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_106017.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables auxin efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables auxin efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adventitious root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auxin export across the plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auxin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cotyledon development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cotyledon morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflorescence development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leaf shaping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photomorphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within shoot system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic embryogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem and phloem pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in ER body	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in plant-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Auxin efflux carrier family protein

NP_177500.1

PIN-FORMED 1 (PIN1); FUNCTIONS IN: transporter activity; INVOLVED IN: in 14 processes; LOCATED IN: apical part of cell, plasma membrane, membrane, basal plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G70940.1); Has 5945 Blast hits to 4479 proteins in 806 species: Archae - 51; Bacteria - 3010; Metazoa - 784; Fungi - 134; Plants - 814; Viruses - 35; Other Eukaryotes - 1117 (source: NCBI BLink).