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    GLR1.4 glutamate receptor 1.4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819940, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLR1.4
    Official Full Name
    glutamate receptor 1.4
    Primary source
    TAIR:AT3G07520
    Locus tag
    AT3G07520
    See related
    Araport:AT3G07520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGLR1.4; glutamate receptor 1.4
    Summary
    member of Putative ligand-gated ion channel subunit family. Contains a functional cation - permeable pore domain. Involved in cellular cation homeostasis.
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    Genomic context

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    See GLR1.4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (2394891..2398291, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Far-red impaired responsive (FAR1) family protein Neighboring gene maternal effect embryo arrest protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene autophagocytosis-associated family protein Neighboring gene integrator complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A plant homolog of animal glutamate receptors is an ion channel gated by multiple hydrophobic amino acids. Tapken D, et al. Sci Signal, 2013 Jun 11. PMID 23757024
    2. Arabidopsis thaliana glutamate receptor ion channel function demonstrated by ion pore transplantation. Tapken D, et al. J Mol Biol, 2008 Oct 31. PMID 18625242
    3. Inter-subunit interactions between glutamate-like receptors in Arabidopsis. Price MB, et al. Plant Signal Behav, 2013. PMID 24300102, Free PMC Article
    4. The identity of plant glutamate receptors. Lacombe B, et al. Science, 2001 May 25. PMID 11379626
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that AtGLR1.4 accounts for methionine-induced membrane depolarization in leaves.
      Title: A plant homolog of animal glutamate receptors is an ion channel gated by multiple hydrophobic amino acids.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111630.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellularly ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 1.4
    NP_187408.2
    • glutamate receptor 1.4 (GLR1.4); FUNCTIONS IN: intracellular ligand-gated ion channel activity, cation channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus, cellular cation homeostasis; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: Glutamate receptor family protein (TAIR:AT5G48400.2); Has 3364 Blast hits to 3306 proteins in 339 species: Archae - 5; Bacteria - 450; Metazoa - 2203; Fungi - 0; Plants - 628; Viruses - 0; Other Eukaryotes - 78 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2394891..2398291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111630.2 → NP_187408.2  glutamate receptor 1.4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187408.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGN1, Q8LGN2, Q9SRR4
      UniProtKB/TrEMBL
      A0A654F508
      Conserved Domains (5) summary
      cd06366
      Location:47 → 410
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      cd13686
      Location:448 → 778
      GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold
      pfam00060
      Location:570 → 810
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:64 → 390
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:476 → 657
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGN1.2

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