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    RAD23C Rad23 UV excision repair protein family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821195, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAD23C
    Official Full Name
    Rad23 UV excision repair protein family
    Primary source
    TAIR:AT3G02540
    Locus tag
    AT3G02540
    See related
    Araport:AT3G02540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16B3.17; F16B3_17; PUTATIVE DNA REPAIR PROTEIN RAD23-3; RAD23-3; RADIATION SENSITIVE23C
    Summary
    Encodes a member of the RADIATION SENSITIVE23 (RAD23) family: AT1G16190(RAD23A), AT1G79650(RAD23B), AT3G02540(RAD23C), AT5G38470(RAD23D). RAD23 proteins play an essential role in the cell cycle, morphology, and fertility of plants through their delivery of UPS (ubiquitin/26S proteasome system) substrates to the 26S proteasome.
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    Genomic context

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    See RAD23C in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (532808..536414, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene general regulatory factor 7 Neighboring gene TCP-1/cpn60 chaperonin family protein Neighboring gene LOB domain-containing protein 41 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RAD23 family provides an essential connection between the 26S proteasome and ubiquitylated proteins in Arabidopsis. Farmer LM, et al. Plant Cell, 2010 Jan. PMID 20086187, Free PMC Article
    2. RAD4 and RAD23/HMR Contribute to Arabidopsis UV Tolerance. Lahari T, et al. Genes (Basel), 2017 Dec 28. PMID 29283431, Free PMC Article
    3. The defective proteasome but not substrate recognition function is responsible for the null phenotypes of the Arabidopsis proteasome subunit RPN10. Lin YL, et al. Plant Cell, 2011 Jul. PMID 21764993, Free PMC Article
    4. Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis. Fatimababy AS, et al. FEBS J, 2010 Feb. PMID 20059542
    5. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202864.1
    NM_202482.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UV protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Rad23 UV excision repair protein family
    NP_001189793.1
    • RADIATION SENSITIVE23C (RAD23C); FUNCTIONS IN: ubiquitin binding, proteasome binding; INVOLVED IN: proteasomal ubiquitin-dependent protein catabolic process, nucleotide-excision repair; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), UV excision repair protein Rad23 (InterPro:IPR004806), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), XPC-binding domain (InterPro:IPR015360), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: Rad23 UV excision repair protein family (TAIR:AT5G38470.1).
    NP_186903.1
    • RADIATION SENSITIVE23C (RAD23C); FUNCTIONS IN: ubiquitin binding, proteasome binding; INVOLVED IN: proteasomal ubiquitin-dependent protein catabolic process, nucleotide-excision repair; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), UV excision repair protein Rad23 (InterPro:IPR004806), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ubiquitin (InterPro:IPR000626), XPC-binding domain (InterPro:IPR015360), Ubiquitin supergroup (InterPro:IPR019955), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: Rad23 UV excision repair protein family (TAIR:AT5G38470.1); Has 42093 Blast hits to 23907 proteins in 1708 species: Archae - 163; Bacteria - 9780; Metazoa - 10471; Fungi - 4857; Plants - 6883; Viruses - 1548; Other Eukaryotes - 8391 (source: NCBI BLink).
    NP_974211.1
    • RADIATION SENSITIVE23C (RAD23C); CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: Rad23 UV excision repair protein family (TAIR:AT5G38470.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      532808..536414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111121.4 → NP_186903.1  Rad23 UV excision repair protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84L31, Q9M887
      UniProtKB/TrEMBL
      A0A178V8E8, A0A5S9X8H5, A0A654F3G6
      Conserved Domains (1) summary
      TIGR00601
      Location:1 → 416
      rad23; UV excision repair protein Rad23

    2. NM_001202864.1 → NP_001189793.1  Rad23 UV excision repair protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V8E8, A0A5S9X8H5, F4JD57
      Conserved Domains (6) summary
      cd01805
      Location:1 → 78
      RAD23_N; Ubiquitin-like domain of RAD23
      cd14379
      Location:180 → 229
      UBA1_Rad23_plant; UBA1 domain of putative DNA repair proteins Rad23 found in plant
      cd14382
      Location:370 → 412
      UBA2_RAD23_plant; UBA2 domain of putative DNA repair proteins RAD23 found in plant
      TIGR00601
      Location:1 → 415
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:289 → 344
      XPC-binding; XPC-binding domain
      cl19863
      Location:227 → 319
      DUF935; Protein of unknown function (DUF935)

    3. NM_202482.3 → NP_974211.1  Rad23 UV excision repair protein family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JD59
      Conserved Domains (3) summary
      cd01805
      Location:1 → 78
      RAD23_N; Ubiquitin-like domain of RAD23
      smart00213
      Location:1 → 74
      UBQ; Ubiquitin homologues
      cd14379
      Location:181 → 230
      UBA1_Rad23_plant; UBA1 domain of putative DNA repair proteins Rad23 found in plant
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84L31.2

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