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    LOX5 PLAT/LH2 domain-containing lipoxygenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821808, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOX5
    Official Full Name
    PLAT/LH2 domain-containing lipoxygenase family protein
    Primary source
    TAIR:AT3G22400
    Locus tag
    AT3G22400
    See related
    Araport:AT3G22400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana lipoxygenase 5; ATLOX5
    Summary
    Encodes lipoxygenase5 (LOX5). LOX5 activity in roots facilitates green peach aphid colonization of Arabidopsis foliage by promoting green peach aphid feeding from sieve element and water consumption from xylem.
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    Genomic context

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    See LOX5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (7926728..7931351)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alternative oxidase 1A Neighboring gene time for coffee Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Root-derived oxylipins promote green peach aphid performance on Arabidopsis foliage. Nalam VJ, et al. Plant Cell, 2012 Apr. PMID 22474183, Free PMC Article
    2. Facilitation of Fusarium graminearum Infection by 9-Lipoxygenases in Arabidopsis and Wheat. Nalam VJ, et al. Mol Plant Microbe Interact, 2015 Oct. PMID 26075826
    3. Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade. Vellosillo T, et al. Plant Cell, 2007 Mar. PMID 17369372, Free PMC Article
    4. Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. Bannenberg G, et al. Lipids, 2009 Feb. PMID 18949503
    5. Lipoxygenase-mediated oxidation of polyunsaturated N-acylethanolamines in Arabidopsis. Kilaru A, et al. J Biol Chem, 2011 Apr 29. PMID 21372125, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plant 9-lipoxygenases (9-LOXs) are engaged during infection to control the balance between salicylic acid (SA) and jasmonic acid (JA) signaling to facilitate infection.
      Title: Facilitation of Fusarium graminearum Infection by 9-Lipoxygenases in Arabidopsis and Wheat.
    2. AtLOX-1 and AtLOX-5 are 9S-lipoxygenases.
      Title: Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_113137.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables linoleate 9S-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PLAT/LH2 domain-containing lipoxygenase family protein
    NP_188879.2
    • LOX5; FUNCTIONS IN: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, lipoxygenase activity, iron ion binding, metal ion binding; INVOLVED IN: root development; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Lipoxygenase, LH2 (InterPro:IPR001024), Lipoxygenase, iron binding site (InterPro:IPR020833), Lipase/lipooxygenase, PLAT/LH2 (InterPro:IPR008976), Lipoxygenase, conserved site (InterPro:IPR020834), Lipoxygenase, C-terminal (InterPro:IPR013819), Lipoxygenase, plant (InterPro:IPR001246); BEST Arabidopsis thaliana protein match is: lipoxygenase 1 (TAIR:AT1G55020.1); Has 1471 Blast hits to 1435 proteins in 177 species: Archae - 0; Bacteria - 82; Metazoa - 527; Fungi - 46; Plants - 787; Viruses - 0; Other Eukaryotes - 29 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7926728..7931351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113137.4 → NP_188879.2  PLAT/LH2 domain-containing lipoxygenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188879.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNX7, Q9LUW0
      UniProtKB/TrEMBL
      A0A5S9XF46
      Conserved Domains (3) summary
      PLN02337
      Location:28 → 886
      PLN02337; lipoxygenase
      cd01751
      Location:33 → 181
      PLAT_LH2; PLAT/ LH2 domain of plant lipoxygenase related proteins. Lipoxygenases are nonheme, nonsulfur iron dioxygenases that act on lipid substrates containing one or more (Z,Z)-1,4-pentadiene moieties. In plants, the immediate products are involved in defense ...
      pfam00305
      Location:193 → 864
      Lipoxygenase; Lipoxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LUW0.2

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