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    Hrd1A RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820854, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hrd1A
    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT3G16090
    Locus tag
    AT3G16090
    See related
    Araport:AT3G16090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHrd1A; homolog of yeast Hrd1
    Summary
    Encodes one of the Arabidopsis homologs of the yeast/human Hrd1 protein: AT3G16090 (Hrd1A), AT1G65040 (Hrd1B). Involved in ERAD (Endoplasmic reticulum-associated degradation).
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    Genomic context

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    See Hrd1A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (5456093..5459006)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ATP binding microtubule motor family protein Neighboring gene LOW protein: ATP-dependent RNA helicase-like protein Neighboring gene Zinc-binding ribosomal protein family protein Neighboring gene RAB GTPase homolog G3C Neighboring gene PDI-like 1-6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis. Wu P, et al. Plant Physiol Biochem, 2021 Oct. PMID 34404006
    2. PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex. Lin L, et al. Nat Commun, 2019 Aug 2. PMID 31375683, Free PMC Article
    3. Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Su W, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187394, Free PMC Article
    4. EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Liu Y, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26371323, Free PMC Article
    5. A user-friendly platform for yeast two-hybrid library screening using next generation sequencing. Erffelinck ML, et al. PLoS One, 2018. PMID 30576311, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.
      Title: Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112479.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of wax biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_188230.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT1G65040.2); Has 7341 Blast hits to 7321 proteins in 267 species: Archae - 0; Bacteria - 4; Metazoa - 2254; Fungi - 727; Plants - 3286; Viruses - 21; Other Eukaryotes - 1049 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5456093..5459006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112479.3 → NP_188230.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188230.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LW77
      UniProtKB/TrEMBL
      A0A178VJM5, A0A5S9XCT1, A0A654F7N5
      Conserved Domains (1) summary
      COG5243
      Location:3 → 386
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LW77.1

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