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    LAG1 TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822140, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LAG1
    Official Full Name
    TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein
    Primary source
    TAIR:AT3G25540
    Locus tag
    AT3G25540
    See related
    Araport:AT3G25540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LAG One Homologue 1; LAG1 HOMOLOG 1; LOH1; LONGEVITY ASSURANCE GENE 1
    Summary
    Encodes a ceramide synthase that together with LOH3 is essential for production of ceramides containing Very Long Chain Fatty acid VLCFA-Ceramides(mainly C 22 to 26).
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    Genomic context

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    See LAG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (9274335..9276685)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5 Neighboring gene glyoxylate reductase 1 Neighboring gene trigger factor Neighboring gene F-box family protein Neighboring gene NSP-interacting kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. Luttgeharm KD, et al. Biochem J, 2016 Mar 1. PMID 26635357
    2. Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance. Luttgeharm KD, et al. Plant Physiol, 2015 Oct. PMID 26276842, Free PMC Article
    3. Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana. Ternes P, et al. New Phytol, 2011 Dec. PMID 21883234
    4. Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis. Markham JE, et al. Plant Cell, 2011 Jun. PMID 21666002, Free PMC Article
    5. ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity. Kimberlin AN, et al. Plant Physiol, 2016 Oct. PMID 27506241, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings indicate that AtORM1 and AtORM2 mediation of serine palmitoyltransferase (SPT) activity differentially regulates functionally distinct ceramide synthase activities as part of a broader sphingolipid homeostatic regulatory network.
      Title: ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity.
    2. The role of At3g25540 in sphingolipid metabolism, mycotoxin resistance and cell death.
      Title: Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance.
    3. Spontaneous cell death in the loh1 line is triggered either by the accumulation of free trihydroxy sphingoid bases or ceramide species with C(16) fatty acid.[LOH1]
      Title: Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001338755.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ceramide phosphoethanolamine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine N-acyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endomembrane system organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein
    NP_001319643.1
    • LONGEVITY ASSURANCE GENE 1 (LAG1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: Golgi apparatus, endoplasmic reticulum, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Longevity assurance, LAG1/LAC1 (InterPro:IPR016439), TRAM/LAG1/CLN8 homology domain (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: LAG1 longevity assurance homolog 3 (TAIR:AT1G13580.3); Has 1255 Blast hits to 1255 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 591; Fungi - 304; Plants - 188; Viruses - 3; Other Eukaryotes - 169 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9274335..9276685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338756.1 → NP_001327930.1  TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LTU4

    2. NM_113450.5 → NP_566769.1  TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566769.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LDF2
      UniProtKB/TrEMBL
      A0A178VEQ4, A0A5S9XFN0
      Conserved Domains (1) summary
      smart00724
      Location:76 → 289
      TLC; TRAM, LAG1 and CLN8 homology domains

    3. NM_001338755.1 → NP_001319643.1  TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LDF2
      UniProtKB/TrEMBL
      A0A178VEQ4, A0A5S9XFN0
      Conserved Domains (1) summary
      smart00724
      Location:76 → 289
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LDF2.1

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