U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GLYR1 glyoxylate reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822139, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GLYR1
    Official Full Name
    glyoxylate reductase 1
    Primary source
    TAIR:AT3G25530
    Locus tag
    AT3G25530
    See related
    Araport:AT3G25530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGHBDH; AtGLYR1; GHBDH; glyoxylate reductase 1; GLYOXYLATE REDUCTASE 1; GR1
    Summary
    Encodes gamma-hydroxybutyrate dehydrogenase (AtGHBDH). Contains a NADP-binding domain. GHBDH is proposed to function in oxidative stress tolerance.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GLYR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (9271515..9273751, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene disease resistance protein (TIR-NBS-LRR class) family protein Neighboring gene ribosomal protein L5 Neighboring gene TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein Neighboring gene trigger factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glyoxylate reductase isoform 1 is localized in the cytosol and not peroxisomes in plant cells. Ching SL, et al. J Integr Plant Biol, 2012 Mar. PMID 22309191
    2. A novel gamma-hydroxybutyrate dehydrogenase: identification and expression of an Arabidopsis cDNA and potential role under oxygen deficiency. Breitkreuz KE, et al. J Biol Chem, 2003 Oct 17. PMID 12882961
    3. Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants. Hoover GJ, et al. Biochim Biophys Acta, 2013 Dec. PMID 24076009
    4. Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification. Simpson JP, et al. J Exp Bot, 2008. PMID 18495639, Free PMC Article
    5. Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms. Allan WL, et al. J Exp Bot, 2008. PMID 18495640, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequence and activity comparisons indicated that AtGLYR1 and AtGLYR2 possess structural features that are absent in Arabidopsis hydroxypyruvate reductases and probably account for their stronger preference for glyoxylate over hydroxypyruvate.
      Title: Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants.
    2. These results define the cytosol as the intracellular location of GLYR1.
      Title: Glyoxylate reductase isoform 1 is localized in the cytosol and not peroxisomes in plant cells.
    3. GR1 and GR2 are involved in the regulation of Succinic semialdehyde detoxification in plants. [glyoxylate reductase 1] [AtGR1]
      Title: Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001035688.1
    NM_001338754.1
    NM_113449.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-hydroxybutyrate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glyoxylate reductase 1
    NP_001030765.1
    • glyoxylate reductase 1 (GLYR1); FUNCTIONS IN: 3-hydroxybutyrate dehydrogenase activity, phosphogluconate dehydrogenase (decarboxylating) activity; INVOLVED IN: response to oxidative stress; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, NAD-binding (InterPro:IPR006115), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), 3-hydroxyacid dehydrogenase/reductase (InterPro:IPR015815), NAD(P)-binding domain (InterPro:IPR016040), 3-hydroxyisobutyrate dehydrogenase-related, conserved site (InterPro:IPR002204); BEST Arabidopsis thaliana protein match is: glyoxylate reductase 2 (TAIR:AT1G17650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566768.1
    • glyoxylate reductase 1 (GLYR1); FUNCTIONS IN: 3-hydroxybutyrate dehydrogenase activity, phosphogluconate dehydrogenase (decarboxylating) activity; INVOLVED IN: response to oxidative stress; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, NAD-binding (InterPro:IPR006115), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), 3-hydroxyacid dehydrogenase/reductase (InterPro:IPR015815), 6-phosphogluconate dehydrogenase (InterPro:IPR006183), NAD(P)-binding domain (InterPro:IPR016040), 3-hydroxyisobutyrate dehydrogenase-related, conserved site (InterPro:IPR002204); BEST Arabidopsis thaliana protein match is: glyoxylate reductase 2 (TAIR:AT1G17650.1); Has 17561 Blast hits to 17531 proteins in 2324 species: Archae - 147; Bacteria - 10853; Metazoa - 400; Fungi - 503; Plants - 354; Viruses - 5; Other Eukaryotes - 5299 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9271515..9273751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113449.4 → NP_566768.1  glyoxylate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS5, F4J913, Q94A74, Q94B07, Q9LSV0
      UniProtKB/TrEMBL
      A0A178VK60, A0A5S9XFP3, A0A654FAM1
      Conserved Domains (1) summary
      COG2084
      Location:1 → 285
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

    2. NM_001338754.1 → NP_001326583.1  glyoxylate reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPQ6

    3. NM_001035688.1 → NP_001030765.1  glyoxylate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAM1
      Conserved Domains (3) summary
      COG2084
      Location:1 → 274
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      pfam03446
      Location:1 → 150
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:153 → 273
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSV0.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.