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    NAI2 DNA topoisomerase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820839, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAI2
    Official Full Name
    DNA topoisomerase-like protein
    Primary source
    TAIR:AT3G15950
    Locus tag
    AT3G15950
    See related
    Araport:AT3G15950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    Similar to TSK-associating protein 1 (TSA1), contains 10 EFE repeats, a novel repeat sequence unique to plants. Expressed preferentially in the roots.Protein is localized to ER bodies- an endoplasmic reticulum derived structure. Loss of function mutations lack ER bodies.
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    Genomic context

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    See NAI2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    28
    Sequence:
    Chromosome: 3; NC_003074.8 (5397541..5402653, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene ncRNA Neighboring gene mismatched DNA binding / ATP binding protein Neighboring gene NUP50 (Nucleoporin 50 kDa) protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae.
      Title: NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae.
    2. AFL1, PDI5, and NAI2 are involved in drought signaling in Arabidopsis thaliana
      Title: At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana.
    3. Data indicate that NAI2 gene (At3g15950) is a key factor that enables ER body formation and the accumulation of PYK10 in ER bodies of Arabidopsis.
      Title: NAI2 is an endoplasmic reticulum body component that enables ER body formation in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035631.2
    NM_001338191.1
    NM_001338192.1
    NM_001338193.1
    NM_112465.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ER body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase-like protein
    NP_001030708.1
    • NAI2; INVOLVED IN: ER body organization, response to salt stress; LOCATED IN: peroxisome, membrane, ER body; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: TSK-associating protein 1 (TAIR:AT1G52410.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_188216.2
    • NAI2; INVOLVED IN: ER body organization, response to salt stress; LOCATED IN: peroxisome, membrane, ER body; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: TSK-associating protein 1 (TAIR:AT1G52410.2); Has 54717 Blast hits to 36231 proteins in 2578 species: Archae - 1044; Bacteria - 11642; Metazoa - 21799; Fungi - 5619; Plants - 2799; Viruses - 308; Other Eukaryotes - 11506 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5397541..5402653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035631.2 → NP_001030708.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F8N8
      Conserved Domains (2) summary
      COG1196
      Location:134 → 469
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK12472
      Location:571 → 713
      PRK12472; hypothetical protein; Provisional

    2. NM_112465.4 → NP_188216.2  DNA topoisomerase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188216.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J1D7, Q712H0, Q9LSB4
      UniProtKB/TrEMBL
      A0A178VJ32, A0A5S9XCQ4
      Conserved Domains (2) summary
      COG1196
      Location:117 → 457
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK12472
      Location:609 → 751
      PRK12472; hypothetical protein; Provisional

    3. NM_001338193.1 → NP_001326808.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQE5

    4. NM_001338192.1 → NP_001326807.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQE4, A0A654F8N8

    5. NM_001338191.1 → NP_001326809.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQE6, A0A654F8N8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSB4.1

    Gene LinkOut

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