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    MKS1 MAP kinase substrate 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821400, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MKS1
    Official Full Name
    MAP kinase substrate 1
    Primary source
    TAIR:AT3G18690
    Locus tag
    AT3G18690
    See related
    Araport:AT3G18690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MAP kinase substrate 1
    Summary
    Encodes a nuclear-localized member of a plant specific gene family involved in mediating responses to pathogens. Interacts with WRKY transcriptional regulators.
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    Genomic context

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    See MKS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (6429534..6430517, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant glycogenin-like starch initiation protein 1 Neighboring gene Ankyrin repeat family protein Neighboring gene Amino acid kinase family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene plant U-box 29

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manipulation of MKS1 gene expression affects Kalanchoë blossfeldiana and Petunia hybrida phenotypes. Gargul JM, et al. Plant Biotechnol J, 2015 Jan. PMID 25082411
    2. Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS1). Caspersen MB, et al. Biochim Biophys Acta, 2007 Sep. PMID 17702678
    3. Constitutive expression of MKS1 confers susceptibility to Botrytis cinerea infection independent of PAD3 expression. Fiil BK, et al. Plant Signal Behav, 2011 Oct. PMID 21900742, Free PMC Article
    4. Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus. Qiu JL, et al. EMBO J, 2008 Aug 20. PMID 18650934, Free PMC Article
    5. Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper function. Petersen K, et al. PLoS One, 2010 Dec 28. PMID 21203436, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study evaluates the effect of manipulating MAP kinase 4 nuclear substrate 1 (MKS1) expression in Kalanchoe blossfeldiana and Petunia hybrida.
      Title: Manipulation of MKS1 gene expression affects Kalanchoë blossfeldiana and Petunia hybrida phenotypes.
    2. MKS1 interacts with the transcription factor WRKY33, which in turn controls the regulation of PAD3 and CYP71A13, two genes, required for proper resistance to B. cinerea.
      Title: Constitutive expression of MKS1 confers susceptibility to Botrytis cinerea infection independent of PAD3 expression.
    3. MKS1 function and subcellular location requires an intact N-terminus important for both MPK4 and WRKY33 interactions
      Title: Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper function.
    4. three of the twelve Ser-Pro serine residues (Ser72, Ser108, Ser120) are in the phosphorylated form.
      Title: Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS1).
    5. MKS1 is required for full salicylic acid-dependent resistance in MAP kinase 4 mutants
      Title: The MAP kinase substrate MKS1 is a regulator of plant defense responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112755.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within innate immune response-activating signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response-activating signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase substrate 1
    NP_566616.1
    • MAP kinase substrate 1 (MKS1); CONTAINS InterPro DOMAIN/s: VQ (InterPro:IPR008889); BEST Arabidopsis thaliana protein match is: VQ motif-containing protein (TAIR:AT1G21326.1); Has 153 Blast hits to 153 proteins in 16 species: Archae - 0; Bacteria - 5; Metazoa - 0; Fungi - 1; Plants - 147; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6429534..6430517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112755.2 → NP_566616.1  MAP kinase substrate 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGD5, Q9LSA8
      UniProtKB/TrEMBL
      A0A654FHG1
      Conserved Domains (1) summary
      pfam05678
      Location:71 → 95
      VQ; VQ motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGD5.2

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