ICK3 Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: ICK3
Official Full Name: Cyclin-dependent kinase inhibitor family protein
Primary source: TAIR:AT3G24810
Locus tag: AT3G24810
See related: Araport:AT3G24810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: kip-related protein 5; KIP-RELATED PROTEIN 5; KRP5
Summary: Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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KRP5 role in gall maturation and root-knot nematode feeding
Title: Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.
KRP5 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the expression of genes required for cell elongation.[KRP5]
Title: Multiple functions of Kip-related protein5 connect endoreduplication and cell elongation.
ICK3/KRP5 is a positive regulator of both cell growth and endoreduplication.
Title: The Arabidopsis CDK inhibitor ICK3/KRP5 is rate limiting for primary root growth and promotes growth through cell elongation and endoreduplication.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_113393.3

Function	Evidence Code	Pubs
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

NP_189125.1

ICK3; FUNCTIONS IN: cyclin-dependent protein kinase inhibitor activity; INVOLVED IN: negative regulation of cyclin-dependent protein kinase activity, cell cycle arrest; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); BEST Arabidopsis thaliana protein match is: inhibitor/interactor with cyclin-dependent kinase (TAIR:AT5G48820.1); Has 195 Blast hits to 195 proteins in 20 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 195; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

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