FMA basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: FMA
Official Full Name: basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source: TAIR:AT3G24140
Locus tag: AT3G24140
See related: Araport:AT3G24140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: FAMA
Summary: Encodes a basic helix-loop-helix transcription factor whose activity is required to promote differentiation of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It fulfills its role through recruitment of the Arabidopsis Retinoblastoma homologue, RETINOBLASTOMA-RELATED (RBR). Both transcript and protein are expressed in and are required for halting divisions at the end of the stomatal lineage. It also has a role in the promotion of guard cell fate and in controlling the transition from guard mother cell to guard cell. Its transcript levels change after inducing MUTE expression in a mute background.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See FMA in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 6

Sequence:: Chromosome: 3; NC_003074.8 (8715118..8718211, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAMA-overexpressed plants displayed enhanced resistance to B. cinerea infection and increased expression levels of defensin genes following B. cinerea treatment. Genetic analysis of MED8 and FAMA suggested that FAMA-regulated pathogen resistance was dependent on MED8. In addition, MED8 and FAMA were both associated with the G-box region in the promoter of ORA59.
Title: The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
Data indicate that the basic helix-loop-helix transcription factor FAMA as an essential component for myrosin cell development along leaf veins.
Title: FAMA is an essential component for the differentiation of two distinct cell types, myrosin cells and guard cells, in Arabidopsis.
Data indicate that loss of the basic helix-loop-helix transcription factor FAMA function abolishes myrosin idioblasts (MIs) fate as well as the expression of the myrosinase genes TGG1 and TGG2.
Title: Myrosin idioblast cell fate and development are regulated by the Arabidopsis transcription factor FAMA, the auxin pathway, and vesicular trafficking.
Irreversible cell fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RBR interaction.
Title: Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
Data indicate that MYB transcription factor FOUR LIPS (FLP) and bHLH transcription factor FAMA complement respective mutant phenotypes.
Title: Deep functional redundancy between FAMA and FOUR LIPS in stomatal development.
Data indicate that bHLH transcription factor FAMA and MYB transcription factor FOUR LIPS (FLP) genes stabilize guard cell fate.
Title: Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes.
Low humidity induces DNA methylation and transcription repression of SPCH and FAMA.
Title: Low relative humidity triggers RNA-directed de novo DNA methylation and suppression of genes controlling stomatal development.
Transcriptional changes in response to inducible expression of Arabidopsis FAMA, a basic helix-loop-helix protein whose actions during the final stage in stomatal development regulate both cell division and cell fate, is reported.
Title: Differentiation of Arabidopsis guard cells: analysis of the networks incorporating the basic helix-loop-helix transcription factor, FAMA.
regulates cell-cell interaction involved in stomatal development.
Title: [Three bHLH master regulators and cell-cell interaction involved in stomatal development].

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001338669.1

Supported by ESTs:

NM_113319.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in guard cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within guard cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guard cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guard cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in guard mother cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to low humidity	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: basic helix-loop-helix (bHLH) DNA-binding superfamily protein

NP_189056.2

FAMA (FMA); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G72210.1); Has 1771 Blast hits to 1747 proteins in 153 species: Archae - 0; Bacteria - 0; Metazoa - 13; Fungi - 80; Plants - 1654; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

8715118..8718211 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113319.5 → NP_189056.2 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189056.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q56YJ8, Q9LRN3

UniProtKB/TrEMBL

A0A178VKX8

Conserved Domains (2) summary

cd04873
Location:328 → 392

ACT_UUR-ACR-like; ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD

cd11448
Location:197 → 268

bHLH_AtFAMA_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins
NM_001338669.1 → NP_001326090.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LN81, A0A654FB56

Conserved Domains (2) summary

cd04873
Location:328 → 392

ACT_UUR-ACR-like; ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD

cd11448
Location:197 → 268

bHLH_AtFAMA_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins