TOPII topoisomerase II [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TOPII
Official Full Name: topoisomerase II
Primary source: TAIR:AT3G23890
Locus tag: AT3G23890
See related: Araport:AT3G23890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATTOPII; topoisomerase II; TOPOISOMERASE II
Summary: Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues.
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Genomic context

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See TOPII in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 20

Sequence:: Chromosome: 3; NC_003074.8 (8624636..8631392)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.
Title: The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

MASC_STS13570 (e-PCR)
- UniSTS:258641

Homology

Orthologs from OrthoDB

NM_001125214.2

Supported by ESTs:

NM_113294.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info
enables DNA topoisomerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA topological change	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: topoisomerase II

NP_001118686.1

topoisomerase II (TOPII); CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, conserved site (InterPro:IPR018522), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit B, domain 2 (InterPro:IPR013506), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA topoisomerase, type IIA, subunit B/N-terminal, alpha-beta (InterPro:IPR013759), DNA topoisomerase, type IIA, subunit B/N-terminal (InterPro:IPR001241), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA topoisomerase II, eukaryotic-type (InterPro:IPR001154), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), DNA topoisomerase, type IIA, central (InterPro:IPR013760); BEST Arabidopsis thaliana protein match is: DNA GYRASE B2 (TAIR:AT5G04130.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_189031.1

topoisomerase II (TOPII); CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, conserved site (InterPro:IPR018522), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), DNA topoisomerase, type IIA, subunit B, domain 2 (InterPro:IPR013506), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA topoisomerase, type IIA, subunit B/N-terminal, alpha-beta (InterPro:IPR013759), DNA topoisomerase, type IIA, subunit B/N-terminal (InterPro:IPR001241), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA topoisomerase II, eukaryotic-type (InterPro:IPR001154), DNA topoisomerase, type IIA, central (InterPro:IPR013760); BEST Arabidopsis thaliana protein match is: DNA GYRASE B2 (TAIR:AT5G04130.1); Has 46226 Blast hits to 43639 proteins in 5982 species: Archae - 169; Bacteria - 28615; Metazoa - 2871; Fungi - 1392; Plants - 616; Viruses - 201; Other Eukaryotes - 12362 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

8624636..8631392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113294.3 → NP_189031.1 topoisomerase II [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189031.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30182, Q38807

UniProtKB/TrEMBL

A0A178VFD9, A0A5S9XF25, A0A654FHS6

Conserved Domains (1) summary

PLN03237
Location:1 → 1459

PLN03237; DNA topoisomerase 2; Provisional
NM_001125214.2 → NP_001118686.1 topoisomerase II [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001118686.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FHS6, B3H4G2

Conserved Domains (6) summary

cd03365
Location:455 → 573

TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...

PLN03237
Location:1 → 1424

PLN03237; DNA topoisomerase 2; Provisional

cd00187
Location:701 → 1166

TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...

cd03481
Location:267 → 419

TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...

pfam02518
Location:80 → 225

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

pfam16898
Location:571 → 699

TOPRIM_C; C-terminal associated domain of TOPRIM