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    UNG uracil dna glycosylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821394, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UNG
    Official Full Name
    uracil dna glycosylase
    Primary source
    TAIR:AT3G18630
    Locus tag
    AT3G18630
    See related
    Araport:AT3G18630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUNG; uracil dna glycosylase
    Summary
    Encodes a uracil-DNA glycosylase (UDG) involved in a base excision DNA repair pathway in mitochondria.
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    Genomic context

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    See UNG in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (6410958..6413196, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene nucleolin like 2 Neighboring gene DHHC-type zinc finger family protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene AGAMOUS-like 103

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis uracil DNA glycosylase (UNG) is required for base excision repair of uracil and increases plant sensitivity to 5-fluorouracil. Córdoba-Cañero D, et al. J Biol Chem, 2010 Mar 5. PMID 20056608, Free PMC Article
    2. Plant mitochondria possess a short-patch base excision DNA repair pathway. Boesch P, et al. Nucleic Acids Res, 2009 Sep. PMID 19625491, Free PMC Article
    3. The Arabidopsis DNA glycosylase MBD4L repairs the nuclear genome in vivo. Torres JR, et al. Plant J, 2023 Sep. PMID 37278489
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that uracil DNA glycosylase AtUNG is the major uracil DNA glycosylase activity in Arabidopsis.
      Title: Arabidopsis uracil DNA glycosylase (UNG) is required for base excision repair of uracil and increases plant sensitivity to 5-fluorouracil.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_112749.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil DNA N-glycosylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uracil dna glycosylase
    NP_188493.1
    • uracil dna glycosylase (UNG); FUNCTIONS IN: uracil DNA N-glycosylase activity; INVOLVED IN: DNA repair, base-excision repair; LOCATED IN: mitochondrion; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Uracil-DNA glycosylase (InterPro:IPR002043), Uracil-DNA glycosylase-like (InterPro:IPR005122); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G10550.1); Has 5606 Blast hits to 5606 proteins in 2219 species: Archae - 2; Bacteria - 4117; Metazoa - 124; Fungi - 141; Plants - 47; Viruses - 234; Other Eukaryotes - 941 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6410958..6413196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112749.5 → NP_188493.1  uracil dna glycosylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188493.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LIH6
      UniProtKB/TrEMBL
      A0A178VFQ0, A0A5S9XDE6
      Conserved Domains (2) summary
      PRK05254
      Location:108 → 330
      PRK05254; uracil-DNA glycosylase; Provisional
      cd10027
      Location:171 → 175
      UDG-F1-like; motif A [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LIH6.1

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