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    GSR2 uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842935, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GSR2
    Official Full Name
    uncharacterized protein
    Primary source
    TAIR:AT1G66200
    Locus tag
    AT1G66200
    See related
    Araport:AT1G66200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGSR2; F15E12.14; F15E12_14; GLN1;2; glutamine synthase clone F11; GLUTAMINE SYNTHETASE; glutamine synthetase 1;2
    Summary
    encodes a cytosolic glutamate synthetase, this enzyme has low affinity with substrate ammonium
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    Genomic context

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    See GSR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (24655115..24657703, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene uncharacterized protein Neighboring gene Subtilisin-like serine endopeptidase family protein Neighboring gene Subtilase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic commitment in the catalysis of glutamine synthesis by GS1 from Arabidopsis using (14)N/(15)N and solvent isotope effects. Mauve C, et al. Plant Physiol Biochem, 2016 Nov. PMID 27448794
    2. The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting. Lothier J, et al. J Exp Bot, 2011 Feb. PMID 20959627
    3. Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity. Guan M, et al. Plant Physiol, 2016 Jul. PMID 27231101, Free PMC Article
    4. Three cytosolic glutamine synthetase isoforms localized in different-order veins act together for N remobilization and seed filling in Arabidopsis. Moison M, et al. J Exp Bot, 2018 Aug 14. PMID 29873769, Free PMC Article
    5. Carbon and amino acids reciprocally modulate the expression of glutamine synthetase in Arabidopsis. Oliveira IC, et al. Plant Physiol, 1999 Sep. PMID 10482686, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutamine biosynthesis for N-remobilization occurs in veins of all orders (major and minor) in leaves, it is mainly catalysed by the three major GS1 isoforms (GLN1;1, GLN1;2, and GLN1;3), and it is alternatively supported by AS2 in the veins and GS2 in the mesophyll cells.
      Title: Three cytosolic glutamine synthetase isoforms localized in different-order veins act together for N remobilization and seed filling in Arabidopsis.
    2. GLN1;2 is the main isozyme contributing to shoot GS1 activity in vegetative growth stages and can be up-regulated to relieve ammonium toxicity.
      Title: Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity.
    3. GLN1;2 catalysis reaction and kinetics
      Title: Kinetic commitment in the catalysis of glutamine synthesis by GS1 from Arabidopsis using (14)N/(15)N and solvent isotope effects.
    4. GLN1;2 (At1g66200) is essential for nitrogen assimilation under ample nitrate supply and for ammonium detoxification.
      Title: The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036163.2
    NM_001198398.1
    NM_105291.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables glutamine synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nitrate assimilation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001031240.1
    • glutamine synthase clone F11 (GSR2); FUNCTIONS IN: glutamate-ammonia ligase activity, copper ion binding; INVOLVED IN: nitrate assimilation, response to fructose stimulus, response to salt stress, response to sucrose stimulus, response to glucose stimulus; LOCATED IN: cytosol, cytosolic ribosome, apoplast, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001185327.1
    • glutamine synthase clone F11 (GSR2); CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1).
    NP_176794.1
    • glutamine synthase clone F11 (GSR2); FUNCTIONS IN: glutamate-ammonia ligase activity, copper ion binding; INVOLVED IN: nitrate assimilation, response to fructose stimulus, response to salt stress, response to sucrose stimulus, response to glucose stimulus; LOCATED IN: cytosol, cytosolic ribosome, apoplast, vacuole, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1); Has 11094 Blast hits to 11090 proteins in 3405 species: Archae - 162; Bacteria - 5924; Metazoa - 440; Fungi - 257; Plants - 1757; Viruses - 3; Other Eukaryotes - 2551 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24655115..24657703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105291.4 → NP_176794.1  uncharacterized protein AT1G66200 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176794.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCE1, Q9C8C7
      UniProtKB/TrEMBL
      A0A178W9R9, A0A5S9WSB2, Q0WWL2
      Conserved Domains (1) summary
      PLN02284
      Location:1 → 354
      PLN02284; glutamine synthetase

    2. NM_001036163.2 → NP_001031240.1  uncharacterized protein AT1G66200 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z2C2, F4ID92
      Conserved Domains (2) summary
      pfam00120
      Location:127 → 251
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:22 → 97
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain

    3. NM_001198398.1 → NP_001185327.1  uncharacterized protein AT1G66200 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4ID91, Q0WWL2
      Conserved Domains (3) summary
      PLN02284
      Location:1 → 363
      PLN02284; glutamine synthetase
      pfam00120
      Location:136 → 357
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:22 → 106
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LCE1.2

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