CRT1a calreticulin 1a [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: CRT1a
Official Full Name: calreticulin 1a
Primary source: TAIR:AT1G56340
Locus tag: AT1G56340
See related: Araport:AT1G56340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtCRT1a; calreticulin 1; CALRETICULIN 1; calreticulin 1a; CRT1; F14G9.5; F14G9_5
Summary: Encodes one of three Arabidopsis calreticulins. In CRT-deficient mouse fibroblasts, this protein restores ER Ca2+ levels.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Arabidopsis PDI11 interacts with lectin molecular chaperons calreticulin 1 and 2 through its D domain.
Title: Arabidopsis PDI11 interacts with lectin molecular chaperons calreticulin 1 and 2 through its D domain.
A triple knockout mutant, t123, which lacks CRT1, CRT2 and CRT3 was generated to examine the roles of calreticulins in abiotic stress tolerance.
Title: Loss of all three calreticulins, CRT1, CRT2 and CRT3, causes enhanced sensitivity to water stress in Arabidopsis.
Dephosphorylation of CRT1 is mediated by PP2A-B'gamma-dependent signaling effects. The dephosphorylated form of CRT1 promotes the degradation of unfolded proteins in ER.
Title: Knock-down of protein phosphatase 2A subunit B'γ promotes phosphorylation of CALRETICULIN 1 in Arabidopsis thaliana.
CRT1 mutants show compromised R gene-mediated resistance to bacterial and oomycete pathogens.
Title: Endosome-associated CRT1 functions early in resistance gene-mediated defense signaling in Arabidopsis and tobacco.
AtCRT1a is an alleviator of the tunicamycin-induced unfolded protein response. [CRT1a]
Title: Functional characterization of Arabidopsis calreticulin1a: a key alleviator of endoplasmic reticulum stress.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_001036122.2

NM_104513.5

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in secretory vesicle	HDA more info	PubMed

NP_001031199.1

calreticulin 1a (CRT1a); FUNCTIONS IN: unfolded protein binding, calcium ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, response to salt stress, calcium ion homeostasis; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Calreticulin/calnexin, P (InterPro:IPR009033), Calreticulin/calnexin (InterPro:IPR001580), Calreticulin/calnexin, conserved site (InterPro:IPR018124), Calreticulin (InterPro:IPR009169), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Concanavalin A-like lectin/glucanase (InterPro:IPR008985); BEST Arabidopsis thaliana protein match is: calreticulin 1b (TAIR:AT1G09210.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_176030.1

calreticulin 1a (CRT1a); FUNCTIONS IN: unfolded protein binding, calcium ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, response to salt stress, calcium ion homeostasis; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Calreticulin/calnexin, P (InterPro:IPR009033), Calreticulin/calnexin (InterPro:IPR001580), Calreticulin/calnexin, conserved site (InterPro:IPR018124), Calreticulin (InterPro:IPR009169), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Concanavalin A-like lectin/glucanase (InterPro:IPR008985); BEST Arabidopsis thaliana protein match is: calreticulin 1b (TAIR:AT1G09210.1); Has 12789 Blast hits to 7186 proteins in 689 species: Archae - 27; Bacteria - 946; Metazoa - 4832; Fungi - 1301; Plants - 669; Viruses - 333; Other Eukaryotes - 4681 (source: NCBI BLink).