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    NSI nuclear shuttle interacting [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840099, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NSI
    Official Full Name
    nuclear shuttle interacting
    Primary source
    TAIR:AT1G32070
    Locus tag
    AT1G32070
    See related
    Araport:AT1G32070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACETYLTRANSFERASE; ATNSI; nuclear shuttle interacting; T12O21.3; T12O21_3
    Summary
    Encodes a nuclear acetyltransferase (NSI)that interacts with the geminivirus movement protein NSP. This interaction is required for viral infection and systemic spread. Acetylates the viral coat protein (CP) in vitro, but not NSP. NSP inhibits NSI activity in vitro. NSI is highly transcribed in phloem and in xylem parenchyma cells, and in the apical meristem and guard cells, within young tissues in Arabidopsis, and its expression is turned off as tissues mature.
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    Genomic context

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    See NSI in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (11534607..11536437, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene SCAMP family protein Neighboring gene phosphoribulokinase Neighboring gene uncharacterized protein Neighboring gene early-responsive to dehydration stress protein (ERD4)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chloroplast Acetyltransferase GNAT2 is Involved in the Organization and Dynamics of Thylakoid Structure. Rantala M, et al. Plant Cell Physiol, 2022 Sep 15. PMID 35792507, Free PMC Article
    2. Interaction of the movement protein NSP and the Arabidopsis acetyltransferase AtNSI is necessary for Cabbage leaf curl geminivirus infection and pathogenicity. Carvalho MF, et al. J Virol, 2004 Oct. PMID 15452236, Free PMC Article
    3. Melatonin Improved Anthocyanin Accumulation by Regulating Gene Expressions and Resulted in High Reactive Oxygen Species Scavenging Capacity in Cabbage. Zhang N, et al. Front Plant Sci, 2016. PMID 27047496, Free PMC Article
    4. Melatonin Regulates Chloroplast Protein Quality Control via a Mitogen-Activated Protein Kinase Signaling Pathway. Lee HY, et al. Antioxidants (Basel), 2021 Mar 25. PMID 33806011, Free PMC Article
    5. Melatonin induction and its role in high light stress tolerance in Arabidopsis thaliana. Lee HY, et al. J Pineal Res, 2018 Oct. PMID 29770489

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084172.1
    NM_102941.3
    NM_202221.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aralkylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within melatonin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect melatonin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melatonin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect mucilage biosynthetic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within photosynthetic state transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within photosynthetic state transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect regulation of anthocyanin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of anthocyanin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect regulation of starch metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to high light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to high light intensity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hydrogen sulfide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hydrogen sulfide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mannitol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect seed oilbody biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transport of virus in multicellular host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nuclear shuttle interacting
    NP_001077641.1
    • nuclear shuttle interacting (NSI); FUNCTIONS IN: N-acetyltransferase activity; INVOLVED IN: pathogenesis, metabolic process, spread of virus in host; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), GCN5-related N-acetyltransferase (InterPro:IPR000182), Acyl-CoA N-acyltransferase (InterPro:IPR016181); BEST Arabidopsis thaliana protein match is: Acyl-CoA N-acyltransferases (NAT) superfamily protein (TAIR:AT1G26220.1); Has 2159 Blast hits to 2159 proteins in 620 species: Archae - 23; Bacteria - 1709; Metazoa - 2; Fungi - 19; Plants - 107; Viruses - 0; Other Eukaryotes - 299 (source: NCBI BLink).
    NP_564387.1
    • nuclear shuttle interacting (NSI); FUNCTIONS IN: N-acetyltransferase activity; INVOLVED IN: pathogenesis, metabolic process, spread of virus in host; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), GCN5-related N-acetyltransferase (InterPro:IPR000182), Acyl-CoA N-acyltransferase (InterPro:IPR016181); BEST Arabidopsis thaliana protein match is: Acyl-CoA N-acyltransferases (NAT) superfamily protein (TAIR:AT1G26220.1); Has 2138 Blast hits to 2138 proteins in 615 species: Archae - 23; Bacteria - 1688; Metazoa - 2; Fungi - 19; Plants - 107; Viruses - 0; Other Eukaryotes - 299 (source: NCBI BLink).
    NP_973950.1
    • nuclear shuttle interacting (NSI); FUNCTIONS IN: N-acetyltransferase activity; INVOLVED IN: pathogenesis, metabolic process, spread of virus in host; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), GCN5-related N-acetyltransferase (InterPro:IPR000182), Acyl-CoA N-acyltransferase (InterPro:IPR016181); BEST Arabidopsis thaliana protein match is: Acyl-CoA N-acyltransferases (NAT) superfamily protein (TAIR:AT1G26220.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11534607..11536437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102941.3 → NP_564387.1  nuclear shuttle interacting [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W676, A0A178W7D4
      Conserved Domains (2) summary
      COG0456
      Location:189 → 243
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:174 → 243
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_202221.2 → NP_973950.1  nuclear shuttle interacting [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRN8, Q7X9V3, Q8LD61, Q9C6X3
      UniProtKB/TrEMBL
      A0A178W676, A0A5S9WKH5, A0A654EFW9
      Conserved Domains (1) summary
      pfam13508
      Location:172 → 244
      Acetyltransf_7; Acetyltransferase (GNAT) domain

    3. NM_001084172.1 → NP_001077641.1  nuclear shuttle interacting [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W676
      Conserved Domains (2) summary
      COG0456
      Location:189 → 243
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:174 → 243
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7X9V3.1

    Gene LinkOut

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