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    AUR1 ataurora1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829419, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AUR1
    Official Full Name
    ataurora1
    Primary source
    TAIR:AT4G32830
    Locus tag
    AT4G32830
    See related
    Araport:AT4G32830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtAUR1; ataurora1; T16I18.40; T16I18_40
    Summary
    Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle. It specifically phosphorylates Ser10 of histone H3 and colocalizes with phosphorylated histone H3 during mitosis.
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    Genomic context

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    See AUR1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (15842443..15844865)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene carotenoid cleavage dioxygenase 8 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene phosphofructokinase 6 Neighboring gene nuclear poly(a) polymerase Neighboring gene Avr9/Cf-9 rapidly elicited protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant Aurora kinases interact with and phosphorylate transcription factors. Takagi M, et al. J Plant Res, 2016 Nov. PMID 27734173
    2. Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication. Petrovská B, et al. New Phytol, 2012 Feb. PMID 22150830
    3. Arabidopsis α Aurora kinases function in formative cell division plane orientation. Van Damme D, et al. Plant Cell, 2011 Nov. PMID 22045917, Free PMC Article
    4. Aurora1 phosphorylation activity on histone H3 and its cross-talk with other post-translational histone modifications in Arabidopsis. Demidov D, et al. Plant J, 2009 Jul. PMID 19582900
    5. Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization. Demidov D, et al. Plant J, 2014 Nov. PMID 25146886

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TPX2-LIKE PROTEIN3 Is the Primary Activator of alpha-Aurora Kinases and Is Essential for Embryogenesis.
      Title: TPX2-LIKE PROTEIN3 Is the Primary Activator of α-Aurora Kinases and Is Essential for Embryogenesis.
    2. AtAUR1 and AtAUR3 have both redundant and distinct functions through interactions with transcription factors (TFs). In addition, database analysis revealed that most of the highly AtAUR-interacting TFs contained a detectable phosphopeptide that was consistent with the consensus motifs for human AURs, suggesting that these TFs are substrates of the AtAURs.
      Title: Plant Aurora kinases interact with and phosphorylate transcription factors.
    3. Aurora kinases play an essential role in the monitoring of meiosis in plants.
      Title: Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization.
    4. a central role for AUR1 kinase in regulating formative division plane orientation throughout development
      Title: Arabidopsis α Aurora kinases function in formative cell division plane orientation.
    5. AtAurora1 kinase may function to phosphorylate substrates that are critical to the spatiotemporal regulation of acentrosomal microtubule formation and organization.
      Title: Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication.
    6. AtAurora1 in vivo kinase activity was inhibited by hesperadin which also inhibited histone H3S10 phosphorylation.
      Title: Aurora1 phosphorylation activity on histone H3 and its cross-talk with other post-translational histone modifications in Arabidopsis.
    7. Aurora kinase AtAUR1 localized at the nuclear membrane in interphase and located in mitotic spindles and cell plates during cell division.
      Title: Characterization of plant Aurora kinases during mitosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119436.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H3S10 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle HDA PubMed 

    General protein information

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    Preferred Names
    ataurora1
    NP_195009.1
    • ataurora1 (AUR1); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora2 (TAIR:AT2G25880.1); Has 130781 Blast hits to 128539 proteins in 4385 species: Archae - 169; Bacteria - 15091; Metazoa - 48154; Fungi - 12951; Plants - 32302; Viruses - 558; Other Eukaryotes - 21556 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15842443..15844865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119436.3 → NP_195009.1  ataurora1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195009.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82309, Q683C9, Q8LBX4, Q9M077
      UniProtKB/TrEMBL
      A0A178V5T5, A0A5S9Y094
      Conserved Domains (1) summary
      cd14007
      Location:30 → 283
      STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M077.1

    Gene LinkOut

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