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    RPN10 regulatory particle non-ATPase 10 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830019, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPN10
    Official Full Name
    regulatory particle non-ATPase 10
    Primary source
    TAIR:AT4G38630
    Locus tag
    AT4G38630
    See related
    Araport:AT4G38630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMCB1; MBP1; MCB1; MULTIUBIQUITIN CHAIN BINDING PROTEIN; MULTIUBIQUITIN CHAIN BINDING PROTEIN 1; MULTIUBIQUITIN-CHAIN-BINDING PROTEIN 1; regulatory particle non-ATPase 10; T9A14.7
    Summary
    Regulatory particle non-ATPase subunit of the 26S proteasome with multiubiquitin-chain-binding capabilities
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    Genomic context

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    See RPN10 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (18056988..18059598, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene myb domain protein 4 Neighboring gene Plasma-membrane choline transporter family protein Neighboring gene Glycosyl hydrolase family 10 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pleiotropic role of the 26S proteasome subunit RPN10 in Arabidopsis growth and development supports a substrate-specific function in abscisic acid signaling. Smalle J, et al. Plant Cell, 2003 Apr. PMID 12671091, Free PMC Article
    2. Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1. Fu H, et al. J Biol Chem, 1998 Jan 23. PMID 9442033
    3. 26S proteasome regulatory particle mutants have increased oxidative stress tolerance. Kurepa J, et al. Plant J, 2008 Jan. PMID 17971041
    4. Characterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains. Galvão RM, et al. Biochem J, 2008 Jan 1. PMID 17880284
    5. ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors. Marshall RS, et al. Cell, 2019 Apr 18. PMID 30955882, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that proteasome subunit RPN10 acts as a proteaphagy receptor by binding ubiquitylated proteasomes and autophagy-related protein ATG8.
      Title: Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis.
    2. Data suggest that RPN10 potentially plays a unique and central role in ubiquitin/proteasome-mediated proteolysis substrate recognition.
      Title: The defective proteasome but not substrate recognition function is responsible for the null phenotypes of the Arabidopsis proteasome subunit RPN10.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120024.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in proteasome core complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle non-ATPase 10
    NP_195575.1
    • regulatory particle non-ATPase 10 (RPN10); FUNCTIONS IN: peptide receptor activity; INVOLVED IN: in 19 processes; LOCATED IN: cytosol, proteasome regulatory particle, base subcomplex, proteasome complex, nucleus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ssl1-like (InterPro:IPR007198), Ubiquitin interacting motif (InterPro:IPR003903), von Willebrand factor, type A (InterPro:IPR002035); Has 677 Blast hits to 665 proteins in 240 species: Archae - 0; Bacteria - 16; Metazoa - 271; Fungi - 148; Plants - 120; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18056988..18059598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120024.3 → NP_195575.1  regulatory particle non-ATPase 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55034, Q8L9G3
      UniProtKB/TrEMBL
      A0A178V4I4, A0A5S9Y091, A0A7G2F961
      Conserved Domains (2) summary
      cd01452
      Location:1 → 189
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
      cd22297
      Location:325 → 372
      PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55034.1

    Gene LinkOut

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