EDS5 MATE efflux family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EDS5
Official Full Name: MATE efflux family protein
Primary source: TAIR:AT4G39030
Locus tag: AT4G39030
See related: Araport:AT4G39030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ENHANCED DISEASE SUSCEPTIBILITY 5; F19H22.130; F19H22_130; SALICYLIC ACID INDUCTION DEFICIENT 1; SCORD3; SID1; susceptible to coronatine-deficient Pst DC3000 3
Summary: Encodes an orphan multidrug and toxin extrusion transporter. Essential component of salicylic acid-dependent signaling for disease resistance. Member of the MATE-transporter family. Expression induced by salicylic acid. Mutants are salicylic acid-deficient.
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Genomic context

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See EDS5 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 12

Sequence:: Chromosome: 4; NC_003075.7 (18185437..18189224)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

iap1-1 is a new allele of EDS5 (eds5-5).
Title: Investigation of intercellular salicylic acid accumulation during compatible and incompatible Arabidopsis-pseudomonas syringae interactions using a fast neutron-generated mutant allele of EDS5 identified by genetic mapping and whole-genome sequencing.
These findings suggest that EDS5 is responsible for transport of salicylic acid from chloroplasts to the cytoplasm in epidermal cells.
Title: Chloroplast envelope localization of EDS5, an essential factor for salicylic acid biosynthesis in Arabidopsis thaliana.
EDS5 functions as a multidrug and toxin extrusion-like transporter in the export of salicylic acid from the chloroplast to the cytoplasm in Arabidopsis, where it controls the innate immune response.
Title: Export of salicylic acid from the chloroplast requires the multidrug and toxin extrusion-like transporter EDS5.
Data suggest hat vtc1-1 mutant requires functional PAD4, EDS5, and NPR1 for SA biosynthesis and pathogen resistance.
Title: Ascorbic acid deficiency in arabidopsis induces constitutive priming that is dependent on hydrogen peroxide, salicylic acid, and the NPR1 gene.
Results suggest that, in addition to R gene-mediated gene-for-gene resistance, EDS5 is also important for basal resistance to viruses.
Title: Overexpression of the Arabidopsis thaliana EDS5 gene enhances resistance to viruses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120063.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	HEP more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in salicylic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within salicylic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: MATE efflux family protein

NP_195614.2

ENHANCED DISEASE SUSCEPTIBILITY 5 (EDS5); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity, transporter activity; INVOLVED IN: salicylic acid biosynthetic process, negative regulation of defense response, defense response, response to nematode; LOCATED IN: mitochondrion, plastid, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT2G21340.1); Has 8328 Blast hits to 8315 proteins in 1724 species: Archae - 197; Bacteria - 6988; Metazoa - 52; Fungi - 30; Plants - 376; Viruses - 0; Other Eukaryotes - 685 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

18185437..18189224

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120063.6 → NP_195614.2 MATE efflux family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195614.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q67ZP3, Q945F0, Q9SVJ0

UniProtKB/TrEMBL

A0A5S9Y0L1, A0A654FX50

Conserved Domains (1) summary

cd13136
Location:98 → 522

MATE_DinF_like; DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins