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    HCC2 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830129, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HCC2
    Official Full Name
    Thioredoxin superfamily protein
    Primary source
    TAIR:AT4G39740
    Locus tag
    AT4G39740
    See related
    Araport:AT4G39740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homologue of copper chaperone SCO1 2; T19P19.130; T19P19_130
    Summary
    Encodes HCC2, one of the two Arabidopsis genes (HCC1 and HCC2) resulting from a duplication with homology to the SCO proteins involved in copper insertion during cytochrome c oxidase (COX) assembly in other organisms. HCC2, which lacks the cysteines and histidine putatively involved in copper binding, functions in copper sensing and redox homeostasis.
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    Genomic context

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    See HCC2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (18435293..18437258, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene VQ motif-containing protein Neighboring gene Lipase/lipooxygenase, PLAT/LH2 family protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene F-box family protein-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plants contain two SCO proteins that are differentially involved in cytochrome c oxidase function and copper and redox homeostasis. Attallah CV, et al. J Exp Bot, 2011 Aug. PMID 21543521
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_120135.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin superfamily protein
    NP_568068.1
    • Thioredoxin superfamily protein; CONTAINS InterPro DOMAIN/s: Copper chaperone SCO1/SenC (InterPro:IPR003782), Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: electron transport SCO1/SenC family protein (TAIR:AT3G08950.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18435293..18437258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120135.5 → NP_568068.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65661, Q8LAL0
      UniProtKB/TrEMBL
      A0A178V000, A0A5S9Y0U0
      Conserved Domains (1) summary
      cd02968
      Location:115 → 255
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LAL0.1

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