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    MDAR1 monodehydroascorbate reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824454, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDAR1
    Official Full Name
    monodehydroascorbate reductase 1
    Primary source
    TAIR:AT3G52880
    Locus tag
    AT3G52880
    See related
    Araport:AT3G52880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMDAR1; monodehydroascorbate reductase 1
    Summary
    Encodes a peroxisomal monodehydroascorbate reductase, involved in the ascorbate-glutathione cycle which removes toxic H2O2
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    Genomic context

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    See MDAR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (19601167..19604597, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene mediator of RNA polymerase II transcription subunit-like protein Neighboring gene ncRNA Neighboring gene IQ calmodulin-binding motif family protein Neighboring gene KCBP-interacting protein kinase Neighboring gene RAB6-interacting golgin (DUF662) Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses. Eltayeb AE, et al. Planta, 2007 Apr. PMID 17043889
    2. Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase. Lisenbee CS, et al. Plant J, 2005 Sep. PMID 16146528
    3. The plasmodesmal protein PDLP1 localises to haustoria-associated membranes during downy mildew infection and regulates callose deposition. Caillaud MC, et al. PLoS Pathog, 2014 Oct. PMID 25393742, Free PMC Article
    4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When expressed in transgenic tobacco, confers enhanced tolerance against ozone, salt and polyethylene glycol stress.
      Title: Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001161202.1
    NM_115148.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monodehydroascorbate reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monodehydroascorbate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hydrogen peroxide catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    monodehydroascorbate reductase 1
    NP_001154674.1
    • monodehydroascorbate reductase 1 (MDAR1); CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: Pyridine nucleotide-disulphide oxidoreductase family protein (TAIR:AT5G03630.1); Has 30852 Blast hits to 30793 proteins in 3038 species: Archae - 685; Bacteria - 24210; Metazoa - 865; Fungi - 584; Plants - 707; Viruses - 0; Other Eukaryotes - 3801 (source: NCBI BLink).
    NP_190856.1
    • monodehydroascorbate reductase 1 (MDAR1); FUNCTIONS IN: monodehydroascorbate reductase (NADH) activity; INVOLVED IN: response to cadmium ion, peptidyl-cysteine S-nitrosylation, hydrogen peroxide catabolic process; LOCATED IN: peroxisomal matrix, apoplast, chloroplast, peroxisome, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: Pyridine nucleotide-disulphide oxidoreductase family protein (TAIR:AT5G03630.1); Has 31553 Blast hits to 31492 proteins in 3048 species: Archae - 709; Bacteria - 24685; Metazoa - 865; Fungi - 647; Plants - 730; Viruses - 0; Other Eukaryotes - 3917 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19601167..19604597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115148.4 → NP_190856.1  monodehydroascorbate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUV6, Q8LBV9, Q9LFA3
      UniProtKB/TrEMBL
      A0A178VLU2, A0A5S9XK85, A0A654FGJ8
      Conserved Domains (1) summary
      pfam07992
      Location:6 → 322
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_001161202.1 → NP_001154674.1  monodehydroascorbate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FGJ8, F4J849
      Conserved Domains (2) summary
      pfam07992
      Location:50 → 354
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      cl21454
      Location:205 → 279
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFA3.1

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