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    TON1A tonneau family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824665, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TON1A
    Official Full Name
    tonneau family protein
    Primary source
    TAIR:AT3G55000
    Locus tag
    AT3G55000
    See related
    Araport:AT3G55000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T15C9.7; TON1; TONNEAU 1; TONNEAU 1A
    Summary
    Encodes a protein of unknown function that is involved in cortical microtubule organization. Mutants exhibit abnormal cell growth and patterns of division. TON1A can functionally complement TON1B and their roles appear to be redundant in plants. Encodes a novel protein that is similar to human FOP and OFD1 centrosomal proteins. Localizes to the preprophase band, cytoplasm and cell cortex where it is probably associated with the cortical cytoskeleton. TON1A associates with plant centrins CEN1 and CEN2.
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    Genomic context

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    See TON1A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (20381460..20383878)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene tonneau 1b (TON1b) Neighboring gene phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana. Wu L, et al. Planta, 2024 Feb 8. PMID 38329545, Free PMC Article
    2. A protein phosphatase 2A complex spatially controls plant cell division. Spinner L, et al. Nat Commun, 2013. PMID 23673648
    3. The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common to plant cortical microtubule arrays and eukaryotic centrosomes. Drevensek S, et al. Plant Cell, 2012 Jan. PMID 22286137, Free PMC Article
    4. Arabidopsis TONNEAU1 proteins are essential for preprophase band formation and interact with centrin. Azimzadeh J, et al. Plant Cell, 2008 Aug. PMID 18757558, Free PMC Article
    5. A tandem affinity purification-based technology platform to study the cell cycle interactome in Arabidopsis thaliana. Van Leene J, et al. Mol Cell Proteomics, 2007 Jul. PMID 17426018

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana.
      Title: TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana.
    2. A protein complex that targets protein phosphatase 2A activity to microtubules, comprises TONNEAU1 and a PP2A heterotrimeric holoenzyme with FASS as regulatory subunit, is recruited to the cytoskeleton via the TONNEAU1-recruiting motif family of proteins.
      Title: A protein phosphatase 2A complex spatially controls plant cell division.
    3. Data show that TRM1 interacts in vivo with TON1 and is able to target TON1 to cortical microtubules via its C-terminal TON1 interaction motif.
      Title: The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common to plant cortical microtubule arrays and eukaryotic centrosomes.
    4. Data show that TON1 protein associates with soluble and microsomal fractions of Arabidopsis cells, and are essential for preprophase band formation and interact with centrin.
      Title: Arabidopsis TONNEAU1 proteins are essential for preprophase band formation and interact with centrin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115357.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in preprophase band assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in preprophase band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tonneau family protein
    NP_567012.1
    • TONNEAU 1A (TON1A); INVOLVED IN: microtubule cytoskeleton organization; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FGFR1 oncogene partner (FOP), N-terminal dimerisation domain (InterPro:IPR018993), LisH dimerisation motif (InterPro:IPR006594); BEST Arabidopsis thaliana protein match is: tonneau 1b (TON1b) (TAIR:AT3G55005.1); Has 229 Blast hits to 226 proteins in 73 species: Archae - 0; Bacteria - 3; Metazoa - 122; Fungi - 0; Plants - 65; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20381460..20383878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115357.4 → NP_567012.1  tonneau family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FQ25
      UniProtKB/TrEMBL
      A0A654FH58, Q8LGF8
      Conserved Domains (2) summary
      pfam09398
      Location:61 → 137
      FOP_dimer; FOP N terminal dimerization domain
      pfam16045
      Location:77 → 104
      LisH_2; LisH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FQ25.1

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