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    PROT2 proline transporter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824740, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PROT2
    Official Full Name
    proline transporter 2
    Primary source
    TAIR:AT3G55740
    Locus tag
    AT3G55740
    See related
    Araport:AT3G55740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPROT2; proline transporter 2; PROLINE TRANSPORTER 2
    Summary
    Encodes a proline transporter with affinity for gly betaine, proline, and GABA. Protein is expressed most highly in the roots.
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    Genomic context

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    See PROT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (20695433..20698292)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene miscRNA Neighboring gene Ribosomal protein L35Ae family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In planta function of compatible solute transporters of the AtProT family. Lehmann S, et al. J Exp Bot, 2011 Jan. PMID 20959625, Free PMC Article
    2. Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutant. Rentsch D, et al. Plant Cell, 1996 Aug. PMID 8776904, Free PMC Article
    3. The AtProT family. Compatible solute transporters with similar substrate specificity but differential expression patterns. Grallath S, et al. Plant Physiol, 2005 Jan. PMID 15618414, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtProT1 and AtProT2 mediate L-proline transport.
      Title: In planta function of compatible solute transporters of the AtProT family.
    2. A new member of the proline transporter gene family, AtProT3, was isolated from Arabidopsis (Arabidopsis thaliana), and its properties were compared to AtProT1 and AtProT2.
      Title: The AtProT family. Compatible solute transporters with similar substrate specificity but differential expression patterns.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339744.1
    NM_115432.5
    NM_202715.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proline transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline transporter 2
    NP_191133.1
    • proline transporter 2 (PROT2); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: proline transporter 1 (TAIR:AT2G39890.2); Has 1444 Blast hits to 1438 proteins in 147 species: Archae - 0; Bacteria - 3; Metazoa - 114; Fungi - 146; Plants - 1153; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).
    NP_974444.1
    • proline transporter 2 (PROT2); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: proline transporter 1 (TAIR:AT2G39890.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20695433..20698292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115432.5 → NP_191133.1  proline transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IY22, P92962
      UniProtKB/TrEMBL
      A0A178VLH0, A0A5S9XLX8, A0A654FG45
      Conserved Domains (1) summary
      cl00456
      Location:32 → 425
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_202715.2 → NP_974444.1  proline transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FG45
      Conserved Domains (1) summary
      cl00456
      Location:1 → 369
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001339744.1 → NP_001325527.1  proline transporter 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FG45
      Conserved Domains (1) summary
      cl00456
      Location:1 → 369
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92962.1

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