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    CPSF100 cleavage and polyadenylation specificity factor 100 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832453, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPSF100
    Official Full Name
    cleavage and polyadenylation specificity factor 100
    Primary source
    TAIR:AT5G23880
    Locus tag
    AT5G23880
    See related
    Araport:AT5G23880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCPSF100; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; cleavage and polyadenylation specificity factor 100; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 100; EMB1265; EMBRYO DEFECTIVE 1265; ENHANCED SILENCING PHENOTYPE 5; ESP5
    Summary
    Encodes a protein similar to the 100kD subunit of cleavage and polyadenylation specificity factor (CPSF), the factor responsible for the recognition of the AAUAAA motif during mRNA polyadenylation. The protein interacts with a portion of a nuclear poly(A) polymerase. It is likely to be a part of the mRNA 3'end formation apparatus.
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    Genomic context

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    See CPSF100 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (8052439..8058465)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tubulin beta 8 Neighboring gene Pectinacetylesterase family protein Neighboring gene GPI-anchored adhesin-like protein Neighboring gene Ribosomal protein L13e family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of cleavage and polyadenylation specificity factor 100: anchoring poly(A) sites and modulating transcription termination. Lin J, et al. Plant J, 2017 Sep. PMID 28621907
    2. Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. Manzano D, et al. Proc Natl Acad Sci U S A, 2009 May 26. PMID 19439664, Free PMC Article
    3. An interaction between an Arabidopsis poly(A) polymerase and a homologue of the 100 kDa subunit of CPSF. Elliott BJ, et al. Plant Mol Biol, 2003 Feb. PMID 12602868
    4. Distinctive interactions of the Arabidopsis homolog of the 30 kD subunit of the cleavage and polyadenylation specificity factor (AtCPSF30) with other polyadenylation factor subunits. Rao S, et al. BMC Cell Biol, 2009 Jul 2. PMID 19573236, Free PMC Article
    5. Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic development. Xing D, et al. Plant Physiol, 2008 Dec. PMID 18971429, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest a key role for CPSF100 in locating poly(A) sites and affecting transcription termination.
      Title: Role of cleavage and polyadenylation specificity factor 100: anchoring poly(A) sites and modulating transcription termination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122293.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor 100
    NP_197776.1
    • cleavage and polyadenylation specificity factor 100 (CPSF100); FUNCTIONS IN: protein binding, DNA binding; INVOLVED IN: mRNA cleavage, mRNA polyadenylation, posttranscriptional gene silencing by RNA, embryo development ending in seed dormancy; LOCATED IN: mRNA cleavage and polyadenylation specificity factor complex, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Beta-Casp domain (InterPro:IPR022712), RNA-metabolising metallo-beta-lactamase (InterPro:IPR011108), Beta-lactamase-like (InterPro:IPR001279); BEST Arabidopsis thaliana protein match is: cleavage and polyadenylation specificity factor 73-I (TAIR:AT1G61010.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8052439..8058465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122293.4 → NP_197776.1  cleavage and polyadenylation specificity factor 100 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FF92, Q9LKF9
      UniProtKB/TrEMBL
      A0A178UFG8
      Conserved Domains (5) summary
      smart01027
      Location:243 → 366
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:12 → 371
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:532 → 569
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      pfam13299
      Location:610 → 736
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      cd16293
      Location:8 → 203
      CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LKF9.2

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