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    SPP Insulinase (Peptidase family M16) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834245, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPP
    Official Full Name
    Insulinase (Peptidase family M16) family protein
    Primary source
    TAIR:AT5G42390
    Locus tag
    AT5G42390
    See related
    Araport:AT5G42390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MDH9.8; MDH9_8; stromal processing peptidase
    Summary
    Encodes a chloroplast-localized metalloprotease that is essential for embryo development. Mutants do not progress normally beyond the 16-cell stage.
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    Genomic context

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    See SPP in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Sequence:
    Chromosome: 5; NC_003076.8 (16945165..16953353)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Calcineurin-like metallo-phosphoesterase superfamily protein Neighboring gene calmodulin like 37 Neighboring gene SET domain protein 25 Neighboring gene SAUR-like auxin-responsive protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that one copy of the SPP gene (At5g42390) is able to produce sufficient SPP protein for normal development under standard growth conditions.
      Title: The stromal processing peptidase of chloroplasts is essential in Arabidopsis, with knockout mutations causing embryo arrest after the 16-cell stage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344443.1
    NM_123604.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Insulinase (Peptidase family M16) family protein
    NP_199054.1
    • Insulinase (Peptidase family M16) family protein; FUNCTIONS IN: metalloendopeptidase activity, zinc ion binding, catalytic activity, metal ion binding; INVOLVED IN: proteolysis; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M16, C-terminal (InterPro:IPR007863), Peptidase M16, N-terminal (InterPro:IPR011765), Metalloenzyme, LuxS/M16 peptidase-like, metal-binding (InterPro:IPR011249), Peptidase M16, core (InterPro:IPR011237); BEST Arabidopsis thaliana protein match is: Insulinase (Peptidase family M16) protein (TAIR:AT5G56730.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16945165..16953353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123604.3 → NP_199054.1  Insulinase (Peptidase family M16) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48870, Q9FIH8
      UniProtKB/TrEMBL
      A0A5S9YAA2, A0A654G7G2
      Conserved Domains (2) summary
      COG0612
      Location:189 → 403
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam05193
      Location:928 → 1156
      Peptidase_M16_C; Peptidase M16 inactive domain

    2. NM_001344443.1 → NP_001331624.1  Insulinase (Peptidase family M16) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEG1, A0A5S9YAA2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FIH8.1

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