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    UBC18 ubiquitin-conjugating enzyme 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834314, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBC18
    Official Full Name
    ubiquitin-conjugating enzyme 18
    Primary source
    TAIR:AT5G42990
    Locus tag
    AT5G42990
    See related
    Araport:AT5G42990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MBD2.19; MBD2_19; ubiquitin-conjugating enzyme 18
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    Genomic context

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    See UBC18 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (17243987..17245988, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Proteasome component (PCI) domain protein Neighboring gene thioredoxin 3 Neighboring gene uncharacterized protein Neighboring gene regulatory particle triple-A ATPase 4A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UBC18 mediates ERF1 degradation under light-dark cycles. Cheng MC, et al. New Phytol, 2017 Feb. PMID 27787902
    2. Arabidopsis OTU1, a linkage-specific deubiquitinase, is required for endoplasmic reticulum-associated protein degradation. Zang Y, et al. Plant J, 2020 Jan. PMID 31491807
    3. The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4. Nagels Durand A, et al. Plant Cell Physiol, 2016 Sep. PMID 27497447
    4. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
    5. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123665.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme 18
    NP_568619.1
    • ubiquitin-conjugating enzyme 18 (UBC18); FUNCTIONS IN: ubiquitin-protein ligase activity, small conjugating protein ligase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: Ubiquitin-conjugating enzyme family protein (TAIR:AT1G45050.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17243987..17245988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123665.5 → NP_568619.1  ubiquitin-conjugating enzyme 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48954, Q9FMM0
      UniProtKB/TrEMBL
      A0A178UL24, A0A5S9YCS7, A0A7G2FH58
      Conserved Domains (1) summary
      pfam00179
      Location:19 → 158
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMM0.1

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