TRX3 thioredoxin 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TRX3
Official Full Name: thioredoxin 3
Primary source: TAIR:AT5G42980
Locus tag: AT5G42980
See related: Araport:AT5G42980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATH3; ATTRX3; ATTRXH3; MBD2.18; MBD2_18; THIOREDOXIN; thioredoxin 3; thioredoxin H-type 3; THIOREDOXIN H3; TRXH3
Summary: encodes a cytosolic thioredoxin that reduces disulfide bridges of target proteins by the reversible formation of a disulfide bridge between two neighboring Cys residues present in the active site. Thioredoxins have been found to regulate a variety of biological reactions in prokaryotic and eukaryotic cells.
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Genomic context

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See TRX3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (17242607..17244231)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtTrx-h3 confers enhanced heat-shock tolerance in Arabidopsis, primarily through its chaperone function.
Title: Heat-shock and redox-dependent functional switching of an h-type Arabidopsis thioredoxin from a disulfide reductase to a molecular chaperone.
regulation of NPR1 is through the opposing action of S-nitrosoglutathione and thioredoxins; findings suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity
Title: Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins.
Data show that thioredoxin h5 (ATTRX5), but not ATTRX3, is highly induced in sensitive Arabidopsis following victorin treatment.
Title: Thioredoxin h5 is required for victorin sensitivity mediated by a CC-NBS-LRR gene in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_123664.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to microbial phytotoxin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: thioredoxin 3

NP_199112.1

thioredoxin 3 (TRX3); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: response to hydrogen peroxide, defense response to fungus, response to microbial phytotoxin; LOCATED IN: in 8 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin H-type 5 (TAIR:AT1G45145.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

17242607..17244231

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123664.4 → NP_199112.1 thioredoxin 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199112.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q42403

UniProtKB/TrEMBL

A0A178U9K5, A0A5S9YAE7

Conserved Domains (1) summary

cd02947
Location:18 → 109

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...