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    SUV2 protein dimerization [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834601, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUV2
    Official Full Name
    protein dimerization
    Primary source
    TAIR:AT5G45610
    Locus tag
    AT5G45610
    See related
    Araport:AT5G45610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MRA19.1; MRA19_1; SENSITIVE TO UV 2
    Summary
    Encodes a homologue of the ATR-interacting protein ATRIP. Mutant (named sensitive to UV2 or suv2) is UVB-hypersensitive and defective in DNA damage response.
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    Genomic context

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    See SUV2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (18496228..18499888, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Proteasome component (PCI) domain protein Neighboring gene senescence regulator (Protein of unknown function, DUF584)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Sjogren CA, et al. Plant Cell Environ, 2017 Sep. PMID 28556304
    2. A UVB-hypersensitive mutant in Arabidopsis thaliana is defective in the DNA damage response. Sakamoto AN, et al. Plant J, 2009 Nov. PMID 19619159
    3. The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors. Sweeney PR, et al. Plant J, 2009 Nov. PMID 19619158
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUV2 was determined to be required for halting cell cycle progression and triggering loss of the quiescent centre (QC) following exposure to Aluminum.
      Title: SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis.
    2. Data suggest that in Arabidopsis, as in yeast and animals, ATRIP acts in complex with ATR (ataxia telangiectasia mutated and rad3-related) to regulate cellular responses to replication blocks and DNA damage. [ATRIP]
      Title: The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001344635.1
    NM_123929.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell cycle G2/M phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to aluminum ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to aluminum ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cisplatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hydroxyurea IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    protein dimerization
    NP_199374.4
    • SENSITIVE TO UV 2 (SUV2); Has 65 Blast hits to 63 proteins in 29 species: Archae - 0; Bacteria - 2; Metazoa - 9; Fungi - 13; Plants - 35; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18496228..18499888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123929.6 → NP_199374.4  protein dimerization [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199374.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8BEL4, C8KI33, Q9FK80
      UniProtKB/TrEMBL
      A0A178U969, A0A5S9YBU4
      Conserved Domains (1) summary
      PLN03205
      Location:1 → 646
      PLN03205; ATR interacting protein; Provisional

    2. NM_001344635.1 → NP_001331674.1  protein dimerization [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G865
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C8KI33.1

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