PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: PAS domain-containing protein tyrosine kinase family protein
Primary source: TAIR:AT5G49470
Locus tag: AT5G49470
See related: Araport:AT5G49470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: K7J8.16; K7J8_16; RAF10
Summary: Encodes a protein with similarity to RAF MAP Kinase that is expressed in most plant tissues. Based on loss of function and gain of function phenotypes, RAF10 appears to be involved in ABA response.
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 12

Sequence:: Chromosome: 5; NC_003076.8 (20063331..20068793)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Raf10 is a novel regulatory component of core abscissic acid signaling.
Title: Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling.
Raf10 and Raf11 kinases are important regulators of seed dormancy and Abscisic acid (ABA) response and that they affect the expression of ABI3, ABI5 and other ABA-regulated genes.
Title: Arabidopsis putative MAP kinase kinase kinases Raf10 and Raf11 are positive regulators of seed dormancy and ABA response.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001203571.1

Supported by ESTs:

NM_001203572.2

Supported by ESTs:

NM_001344845.1

Supported by ESTs:

NM_001344846.1

Supported by ESTs:

NM_001344847.1

Supported by ESTs:

NM_203185.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: PAS domain-containing protein tyrosine kinase family protein

NP_001190500.1

PAS domain-containing protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation, regulation of transcription, DNA-dependent; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: PAS fold (InterPro:IPR013767), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: PAS domain-containing protein tyrosine kinase family protein (TAIR:AT1G67890.1).

NP_001190501.1

PAS domain-containing protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, kinase activity; INVOLVED IN: signal transduction, protein amino acid phosphorylation, regulation of transcription, DNA-dependent; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: PAS fold (InterPro:IPR013767), Serine/threonine-protein kinase domain (InterPro:IPR002290), PAS (InterPro:IPR000014), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: PAS domain-containing protein tyrosine kinase family protein (TAIR:AT1G67890.1).

NP_199758.2

PAS domain-containing protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: PAS domain-containing protein tyrosine kinase family protein (TAIR:AT1G67890.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974914.2

PAS domain-containing protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, kinase activity; INVOLVED IN: signal transduction, protein amino acid phosphorylation, regulation of transcription, DNA-dependent; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: PAS fold (InterPro:IPR013767), Serine/threonine-protein kinase domain (InterPro:IPR002290), PAS (InterPro:IPR000014), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: PAS domain-containing protein tyrosine kinase family protein (TAIR:AT1G67890.1); Has 121247 Blast hits to 111226 proteins in 3334 species: Archae - 299; Bacteria - 14307; Metazoa - 45307; Fungi - 9630; Plants - 33090; Viruses - 453; Other Eukaryotes - 18161 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

20063331..20068793

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124324.4 → NP_199758.2 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199758.2

Status: REVIEWED

UniProtKB/TrEMBL

F4K647

Conserved Domains (2) summary

cd13999
Location:210 → 456

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases

pfam07714
Location:204 → 456

Pkinase_Tyr; Protein tyrosine kinase
NM_001203572.2 → NP_001190501.1 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190501.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UGB9, A0A654G9E4, F4K644

Conserved Domains (2) summary

cd13999
Location:497 → 743

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases

pfam00989
Location:100 → 210

PAS; PAS fold
NM_001344845.1 → NP_001331498.1 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UF35, A0A1P8BE34
NM_001344846.1 → NP_001331497.1 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UF35, A0A1P8BE22

Conserved Domains (2) summary

cd13999
Location:497 → 696

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases

pfam00989
Location:100 → 210

PAS; PAS fold
NM_001344847.1 → NP_001331499.1 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BE48, A0A7G2FLF5

Conserved Domains (1) summary

cd13999
Location:370 → 616

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
NM_203185.2 → NP_974914.2 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974914.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A654G9E4, F4K645

Conserved Domains (4) summary

cd00130
Location:109 → 210

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd13999
Location:494 → 804

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases

pfam00989
Location:100 → 210

PAS; PAS fold

pfam07714
Location:488 → 804

Pkinase_Tyr; Protein tyrosine kinase
NM_001203571.1 → NP_001190500.1 PAS domain-containing protein tyrosine kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190500.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654G9E4, F4K646

Conserved Domains (2) summary

cd13999
Location:471 → 717

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases

pfam07714
Location:465 → 717

Pkinase_Tyr; Protein tyrosine kinase