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    FSD2 Fe superoxide dismutase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835183, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FSD2
    Official Full Name
    Fe superoxide dismutase 2
    Primary source
    TAIR:AT5G51100
    Locus tag
    AT5G51100
    See related
    Araport:AT5G51100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Fe superoxide dismutase 2; MWD22.4; MWD22_4
    Summary
    Fe superoxide dismutase whose mRNA levels are increased in response to exposure to UV-B.
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    Genomic context

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    See FSD2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (20773235..20775739, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Transcriptional coactivator/pterin dehydratase Neighboring gene ECA1 gametogenesis family protein (DUF1278) Neighboring gene polyadenylate-binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Plastid-Encoded RNA Polymerase-Associated Protein PAP9 Is a Superoxide Dismutase With Unusual Structural Features. Favier A, et al. Front Plant Sci, 2021. PMID 34276730, Free PMC Article
    2. LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2. Garcia-Molina A, et al. J Exp Bot, 2017 Feb 1. PMID 28207043, Free PMC Article
    3. A heterocomplex of iron superoxide dismutases defends chloroplast nucleoids against oxidative stress and is essential for chloroplast development in Arabidopsis. Myouga F, et al. Plant Cell, 2008 Nov. PMID 18996978, Free PMC Article
    4. PRDA1, a novel chloroplast nucleoid protein, is required for early chloroplast development and is involved in the regulation of plastid gene expression in Arabidopsis. Qiao J, et al. Plant Cell Physiol, 2013 Dec. PMID 24132784
    5. Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization. Kliebenstein DJ, et al. Plant Physiol, 1998 Oct. PMID 9765550, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LSU1 interacts with the chloroplastic superoxide dismutase FSD2 and stimulates its enzymatic activity in vivo and in vitro. Pseudomonas syringae virulence effectors interfere with this interaction and preclude re-localization of LSU1 to chloroplasts.
      Title: LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.
    2. FSD2 and FSD3 act as ROS scavengers in the maintenance of early chloroplast development by protecting the chloroplast nucleoids from ROS.
      Title: A heterocomplex of iron superoxide dismutases defends chloroplast nucleoids against oxidative stress and is essential for chloroplast development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344920.1
    NM_001344921.1
    NM_124489.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast nucleoid HDA PubMed 
    located_in chloroplast nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of plastid-encoded plastid RNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fe superoxide dismutase 2
    NP_199923.1
    • Fe superoxide dismutase 2 (FSD2); FUNCTIONS IN: superoxide dismutase activity; INVOLVED IN: response to UV; LOCATED IN: chloroplast, nucleoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 1 (TAIR:AT4G25100.5); Has 11522 Blast hits to 11521 proteins in 3361 species: Archae - 194; Bacteria - 8106; Metazoa - 433; Fungi - 799; Plants - 399; Viruses - 1; Other Eukaryotes - 1590 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20773235..20775739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344919.1 → NP_001330687.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBM1

    2. NM_001344918.1 → NP_001330683.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBM1

    3. NM_001344917.1 → NP_001330684.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK0

    4. NM_124489.3 → NP_199923.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04879, Q9LU64
      UniProtKB/TrEMBL
      A0A178UQJ4
      Conserved Domains (3) summary
      PLN02685
      Location:5 → 305
      PLN02685; iron superoxide dismutase
      pfam00081
      Location:53 → 136
      Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
      pfam02777
      Location:144 → 262
      Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

    5. NM_001344920.1 → NP_001330686.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UQJ4, A0A1P8BBJ5

    6. NM_001344921.1 → NP_001330685.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LU64.1

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