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    ACS12 1-amino-cyclopropane-1-carboxylate synthase 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835243, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACS12
    Official Full Name
    1-amino-cyclopropane-1-carboxylate synthase 12
    Primary source
    TAIR:AT5G51690
    Locus tag
    AT5G51690
    See related
    Araport:AT5G51690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    1-amino-cyclopropane-1-carboxylate synthase 12; MIO24.18; MIO24_18
    Summary
    Encodes an aminotransferase with broad specificity for aspartate and aromatic amino aids such as tyrosine and phenylalanine. It does not act on branched chain amino acids and does not have ACC synthase activity.
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    Genomic context

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    See ACS12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (20997413..21001054, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF668) Neighboring gene ncRNA Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene cysteine and histidine-rich domain-containing protein RAR1 Neighboring gene K+ efflux antiporter 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical diversity among the 1-amino-cyclopropane-1-carboxylate synthase isozymes encoded by the Arabidopsis gene family. Yamagami T, et al. J Biol Chem, 2003 Dec 5. PMID 12968022
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001344953.1
    NM_124548.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-aspartate:2-oxoglutarate aminotransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables aromatic-amino-acid transaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    1-amino-cyclopropane-1-carboxylate synthase 12
    NP_199982.2
    • 1-amino-cyclopropane-1-carboxylate synthase 12 (ACS12); CONTAINS InterPro DOMAIN/s: Aminotransferase, class I/classII (InterPro:IPR004839), 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: ACC synthase 10 (TAIR:AT1G62960.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20997413..21001054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124548.5 → NP_199982.2  1-amino-cyclopropane-1-carboxylate synthase 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199982.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GYY0, Q9C5W4, Q9FLJ0
      UniProtKB/TrEMBL
      A0A178UBF0, Q570P9
      Conserved Domains (3) summary
      cd00609
      Location:148 → 488
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PLN02450
      Location:70 → 495
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase
      cl18945
      Location:81 → 213
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_001344953.1 → NP_001330155.1  1-amino-cyclopropane-1-carboxylate synthase 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9X4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GYY0.2

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