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    CUC2 NAC (No Apical Meristem) domain transcriptional regulator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835478, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CUC2
    Official Full Name
    NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
    Primary source
    TAIR:AT5G53950
    Locus tag
    AT5G53950
    See related
    Araport:AT5G53950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANAC098; Arabidopsis NAC domain containing protein 98; ATCUC2; CUP-SHAPED COTYLEDON 2; K19P17.12; K19P17_12
    Summary
    Transcriptional activator of the NAC gene family, with CUC1 redundantly required for embryonic apical meristem formation, cotyledon separation and expression of STM. Proper timing of CUC2 expression is required to maintain the phyllotactic pattern initiated in the meristem. CUC2 expression in leaf sinus region is required for serration and the extent of serration is modulated by mir164A mediated repression of CUC2.
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    Genomic context

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    See CUC2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (21901704..21903854, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11 methyltransferase-like protein Neighboring gene transcriptional regulator ATRX-like protein Neighboring gene Yippee family putative zinc-binding protein Neighboring gene Mid-1-related chloride channel domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shoot apical meristem and cotyledon formation during Arabidopsis embryogenesis: interaction among the CUP-SHAPED COTYLEDON and SHOOT MERISTEMLESS genes. Aida M, et al. Development, 1999 Apr. PMID 10079219
    2. Plants expressing a miR164-resistant CUC2 gene reveal the importance of post-meristematic maintenance of phyllotaxy in Arabidopsis. Peaucelle A, et al. Development, 2007 Mar. PMID 17251269
    3. A microRNA-transcription factor module regulates lateral organ size and patterning in Arabidopsis. Larue CT, et al. Plant J, 2009 May. PMID 19154203
    4. Mechanisms of leaf tooth formation in Arabidopsis. Kawamura E, et al. Plant J, 2010 May. PMID 20128880
    5. CUC2 as an early marker for regeneration competence in Arabidopsis root explants. Motte H, et al. J Plant Physiol, 2011 Sep 1. PMID 21507507

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study's results demonstrate a role for UGT85A3 and UGT73C1 as a link between CUP-SHAPED COTYLEDON 1 (CUC1) and CUC2, and cytokinin (CK) homeostasis, and highlight the importance of CUCs and CKs in the determination of seed yield.
      Title: CUP-SHAPED COTYLEDON1 (CUC1) and CUC2 regulate cytokinin homeostasis to determine ovule number in Arabidopsis.
    2. we show that CUC2 acts as a trigger to promote growth through the activation of three functional relays. In particular, we show that KLUH acts downstream of CUC2 to modulate auxin response and that expressing KLUH can compensate for deficient CUC2 expression during tooth growth.
      Title: Dissecting the pathways coordinating patterning and growth by plant boundary domains.
    3. Genetic analysis established that SVR9/SVR9-LIKE1 (SVR9L1)-mediated leaf margin development is dependent on CUP-SHAPED COTYLEDON2 (CUC2) activities and is independent of their roles in chloroplast development.
      Title: Chloroplast Translation Initiation Factors Regulate Leaf Variegation and Development.
    4. The cuc2 cuc3 double mutant displays irregular phyllotaxis in the mature shoot but not in the shoot apex, thus showing a post-meristematic effect of the mutations on phyllotaxis.
      Title: The CUP-SHAPED COTYLEDON2 and 3 genes have a post-meristematic effect on Arabidopsis thaliana phyllotaxis.
    5. PLT3, PLT5, and PLT7 additionally regulate and require the shoot-promoting factor CUP-SHAPED COTYLEDON2 (CUC2) to complete the shoot-formation program.
      Title: PLETHORA Genes Control Regeneration by a Two-Step Mechanism.
    6. cuc1 grf1/2/3, cuc2 grf1/2/3, and cuc3 grf1/2/3 quadruple mutants showed dramatic increases in cotyledon fusion as well as floral organ fusion.
      Title: Genetic interaction between GROWTH-REGULATING FACTOR and CUP-SHAPED COTYLEDON in organ separation.
    7. Cup-shaped cotyledon (CUC)1, CUC2, and AINTEGUMENTA (ANT) have additive effects on ovule primordia formation.
      Title: An integrative model of the control of ovule primordia formation.
    8. CUC2 is a predictive marker for the acquisition of root explant competence for root and shoot organogenesis.
      Title: CUC2 as an early marker for regeneration competence in Arabidopsis root explants.
    9. SPT negatively regulates CUC1 and CUC2 expression in the apical part of the gynoecium.
      Title: Interactions of CUP-SHAPED COTYLEDON and SPATULA genes control carpel margin development in Arabidopsis thaliana.
    10. DPA4 expression domains overlap with those of the known leaf shape regulator CUP-SHAPED COTYLEDON 2 (CUC2) and we provide evidence that DPA4 negatively regulates CUC2 expression independently of MIR164A, an established regulator of CUC2
      Title: Development-related PcG target in the apex 4 controls leaf margin architecture in Arabidopsis thaliana.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124774.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within formation of plant organ boundary IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary shoot apical meristem specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of timing of plant organ formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
    NP_200206.1
    • CUP-SHAPED COTYLEDON 2 (CUC2); CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: NAC (No Apical Meristem) domain transcriptional regulator superfamily protein (TAIR:AT3G15170.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21901704..21903854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124774.3 → NP_200206.1  NAC (No Apical Meristem) domain transcriptional regulator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04017
      UniProtKB/TrEMBL
      A0A178UAW2, A0A5S9YE20
      Conserved Domains (1) summary
      pfam02365
      Location:18 → 144
      NAM; No apical meristem (NAM) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04017.1

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