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    WRKY2 WRKY DNA-binding protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835726, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WRKY2
    Official Full Name
    WRKY DNA-binding protein 2
    Primary source
    TAIR:AT5G56270
    Locus tag
    AT5G56270
    See related
    Araport:AT5G56270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA WRKY DNA-BINDING PROTEIN 2; ATWRKY2; MXK23.1; MXK23_1; WRKY DNA-binding protein 2
    Summary
    Encodes WRKY transcription factor 2, a zinc-finger protein. In wrky2 mutants, egg cells polarize normally but zygotes fail to reestablish polar organelle positioning from a transient symmetric state, resulting in equal cell division and distorted embryo development.
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    Genomic context

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    See WRKY2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (22779614..22783426)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene hapless 8 Neighboring gene ncRNA Neighboring gene Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase Neighboring gene COP9 signalosome subunit 6A Neighboring gene peroxin 5 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis WRKY2 transcription factor mediates seed germination and postgermination arrest of development by abscisic acid. Jiang W, et al. BMC Plant Biol, 2009 Jul 22. PMID 19622176, Free PMC Article
    2. Crystal structures of N-terminal WRKY transcription factors and DNA complexes. Xu YP, et al. Protein Cell, 2020 Mar. PMID 31734872, Free PMC Article
    3. Arabidopsis WRKY2 and WRKY34 transcription factors interact with VQ20 protein to modulate pollen development and function. Lei R, et al. Plant J, 2017 Sep. PMID 28635025
    4. Phosphorylation of a WRKY transcription factor by MAPKs is required for pollen development and function in Arabidopsis. Guan Y, et al. PLoS Genet, 2014. PMID 24830428, Free PMC Article
    5. Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development. Ueda M, et al. Dev Cell, 2011 Feb 15. PMID 21316593

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structures of N-terminal WRKY transcription factors and DNA complexes.
      Title: Crystal structures of N-terminal WRKY transcription factors and DNA complexes.
    2. The study provides evidence that VQ20 acts as a key partner of WRKY2 and WKRY34 in plant male gametogenesis.
      Title: Arabidopsis WRKY2 and WRKY34 transcription factors interact with VQ20 protein to modulate pollen development and function.
    3. Epistasis interaction analysis confirmed that MPK6 belongs to the same genetic pathway of WRKY34 and WRKY2
      Title: Phosphorylation of a WRKY transcription factor by MAPKs is required for pollen development and function in Arabidopsis.
    4. wrky2 mutants are hypersensitive to ABA responses during postgermination growth.
      Title: Arabidopsis WRKY2 transcription factor mediates seed germination and postgermination arrest of development by abscisic acid.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125010.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within longitudinal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WRKY DNA-binding protein 2
    NP_200438.1
    • WRKY DNA-binding protein 2 (WRKY2); CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657); BEST Arabidopsis thaliana protein match is: WRKY DNA-binding protein 34 (TAIR:AT4G26440.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22779614..22783426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125010.3 → NP_200438.1  WRKY DNA-binding protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FG77
      UniProtKB/TrEMBL
      A0A178US56, A0A654GCI7
      Conserved Domains (2) summary
      smart00774
      Location:486 → 543
      WRKY; DNA binding domain
      pfam03106
      Location:274 → 328
      WRKY; WRKY DNA -binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FG77.1

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