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    HAG2 histone acetyltransferase of the GNAT family 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835775, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAG2
    Official Full Name
    histone acetyltransferase of the GNAT family 2
    Primary source
    TAIR:AT5G56740
    Locus tag
    AT5G56740
    See related
    Araport:AT5G56740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HAC07; HAC7; HAG02; histone acetyltransferase of the GNAT family 2; MIK19.19; MIK19_19
    Summary
    Encodes an enzyme with histone acetyltransferase activity. Histone H4 is the primary substrate for the enzyme. Prior acetylation of lysine 12 of histone H4 reduces radioactive acetylation by HAG2. HAG2 acetylates histone H4 lysine 12.
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    Genomic context

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    See HAG2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (22952767..22955739, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Lactate/malate dehydrogenase family protein Neighboring gene Insulinase (Peptidase family M16) protein Neighboring gene tRNA-Pro Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation. Earley KW, et al. Plant J, 2007 Nov. PMID 17877703
    2. Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Earley K, et al. Genes Dev, 2006 May 15. PMID 16648464, Free PMC Article
    3. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Pandey R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466527, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345215.1
    NM_125057.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in subtelomeric heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the GNAT family 2
    NP_200485.1
    • histone acetyltransferase of the GNAT family 2 (HAG2); FUNCTIONS IN: histone acetyltransferase activity, H4 histone acetyltransferase activity; INVOLVED IN: histone acetylation, chromatin modification, chromatin silencing at telomere; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone acetyltransferase type B, catalytic subunit (InterPro:IPR017380), GCN5-related N-acetyltransferase, C-terminal (InterPro:IPR022610), Acyl-CoA N-acyltransferase (InterPro:IPR016181), Histone acetyl transferase HAT1 N-terminal (InterPro:IPR019467); Has 368 Blast hits to 368 proteins in 193 species: Archae - 0; Bacteria - 0; Metazoa - 119; Fungi - 147; Plants - 50; Viruses - 0; Other Eukaryotes - 52 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22952767..22955739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125057.4 → NP_200485.1  histone acetyltransferase of the GNAT family 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LKJ6, Q9FJT8
      UniProtKB/TrEMBL
      A0A178UNR1, A0A5S9YEL8, A0A654GBT7, Q1JPN3
      Conserved Domains (2) summary
      cd04301
      Location:225 → 283
      NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
      pfam10394
      Location:29 → 195
      Hat1_N; Histone acetyl transferase HAT1 N-terminus

    2. NM_001345215.1 → NP_001331990.1  histone acetyltransferase of the GNAT family 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNR1, A0A1P8BFL5, A0A654GBT7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJT8.1

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