MKK6 MAP kinase kinase 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MKK6
Official Full Name: MAP kinase kinase 6
Primary source: TAIR:AT5G56580
Locus tag: AT5G56580
See related: Araport:AT5G56580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ANQ1; ARABIDOPSIS NQK1; ARABIDOPSIS THALIANA MAP KINASE KINASE 6; ATMKK6; MAP kinase kinase 6; MIK19.2; MIK19_2
Summary: Encodes a member of the MAP Kinase Kinase family of proteins. It can phosphorylate MPK12 in vitro and it can be dephosphorylated by MKP2 in vitro.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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The study shows that MKK6 has multiple functions in plant defense responses in addition to cytokinesis.
Title: MKK6 Functions in Two Parallel MAP Kinase Cascades in Immune Signaling.
Arabidopsis MPK4 can interact with and be phosphorylated by the cytokinesis-related MAP kinase kinase, AtMKK6.
Title: AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis.
AtMKK6-AtMPK13 module positively regulates lateral root formation.
Title: AtMKK6 and AtMPK13 are required for lateral root formation in Arabidopsis.
Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.
Title: HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_125041.3

Function	Evidence Code	Pubs
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	TAS Traceable Author Statement more info	PubMed
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to oomycetes	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed

NP_200469.1

MAP kinase kinase 6 (MKK6); FUNCTIONS IN: MAP kinase kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 2 (TAIR:AT4G29810.1); Has 125172 Blast hits to 123800 proteins in 4446 species: Archae - 151; Bacteria - 14363; Metazoa - 46867; Fungi - 12279; Plants - 30893; Viruses - 513; Other Eukaryotes - 20106 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain