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    eIFiso4G1 MIF4G domain-containing protein / MA3 domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835897, updated on 18-Sep-2024

    Summary

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    Official Symbol
    eIFiso4G1
    Official Full Name
    MIF4G domain-containing protein / MA3 domain-containing protein
    Primary source
    TAIR:AT5G57870
    Locus tag
    AT5G57870
    See related
    Araport:AT5G57870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    eukaryotic translation Initiation Factor isoform 4G1; MTI20.13; MTI20_13
    Summary
    Encodes a putative eukaryotic translation initiation factor
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    Genomic context

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    See eIFiso4G1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (23439498..23443815)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene Ubiquitin-like superfamily protein Neighboring gene ncRNA Neighboring gene multipolar spindle 1 Neighboring gene tRNA-Met Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of eIFiso4G1 mutation on seed oil biosynthesis. Li Q, et al. Plant J, 2017 Jun. PMID 28244172
    2. The SnRK1-eIFiso4G1 signaling relay regulates the translation of specific mRNAs in Arabidopsis under submergence. Cho HY, et al. New Phytol, 2019 Apr. PMID 30414328
    3. Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis. Gallie DR. J Biol Chem, 2016 Jan 15. PMID 26578519, Free PMC Article
    4. Deletion of the eIFiso4G subunit of the Arabidopsis eIFiso4F translation initiation complex impairs health and viability. Lellis AD, et al. Plant Mol Biol, 2010 Oct. PMID 20694742, Free PMC Article
    5. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function. Lellis AD, et al. Plant Physiol, 2019 Sep. PMID 31308150, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
      Title: eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
    2. SOAR1 inhibits interactions of eIFiso4E, eIF4Es, eIF4A1, eIF4B2 and poly(A)-binding protein PAB6 with eIFiso4G1 and eIFiso4G2, thereby inhibiting eIFiso4F/mixed eIF4F assembly and repressing translation initiation
      Title: Arabidopsis translation initiation factors eIFiso4G1/2 link repression of mRNA cap-binding complex eIFiso4F assembly with RNA-binding protein SOAR1-mediated ABA signaling.
    3. the SnRK1-eIFiso4G1 relay controls the translation of an array of genes under hypoxia.
      Title: The SnRK1-eIFiso4G1 signaling relay regulates the translation of specific mRNAs in Arabidopsis under submergence.
    4. study on a mutant of eIFiso4G1 uncovered multifaceted interactions between the cytosolic and plastidic compartments in seed lipid biosynthesis that impact major seed oil traits.
      Title: Effects of eIFiso4G1 mutation on seed oil biosynthesis.
    5. Data (including phylogenetic analysis) suggest that eukaryotic translation initiation factors eIF4G1/eIF(iso)4G1 and eIF4G2/eIF(iso)4G2 exhibit differences in ability to promote translation initiation. [eIF4G1]
      Title: Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis.
    6. Single and double knockout deletions of eIFis4G1 (i4g1) and eIFiso4G2 (i4g2) genes in A. thaliana reduce the amounts of chlorophyll a and b, suggesting a role in the expression of chloroplast proteins. [i4g1] [eIFiso4G1]
      Title: Deletion of the eIFiso4G subunit of the Arabidopsis eIFiso4F translation initiation complex impairs health and viability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125172.2
    NM_180876.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    MIF4G domain-containing protein / MA3 domain-containing protein
    NP_200595.2
    • eukaryotic translation Initiation Factor isoform 4G1 (eIFiso4G1); FUNCTIONS IN: RNA binding, binding, translation initiation factor activity; INVOLVED IN: translational initiation, translation, RNA metabolic process; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor eIF-4 gamma, MA3 (InterPro:IPR003891), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); BEST Arabidopsis thaliana protein match is: MIF4G domain-containing protein / MA3 domain-containing protein (TAIR:AT2G24050.1); Has 2168 Blast hits to 1785 proteins in 242 species: Archae - 0; Bacteria - 22; Metazoa - 1155; Fungi - 192; Plants - 508; Viruses - 0; Other Eukaryotes - 291 (source: NCBI BLink).
    NP_851207.1
    • eukaryotic translation Initiation Factor isoform 4G1 (eIFiso4G1); FUNCTIONS IN: RNA binding, binding, translation initiation factor activity; INVOLVED IN: translational initiation, translation, RNA metabolic process; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor eIF-4 gamma, MA3 (InterPro:IPR003891), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); BEST Arabidopsis thaliana protein match is: MIF4G domain-containing protein / MA3 domain-containing protein (TAIR:AT2G24050.1); Has 2162 Blast hits to 1779 proteins in 243 species: Archae - 0; Bacteria - 22; Metazoa - 1156; Fungi - 189; Plants - 508; Viruses - 0; Other Eukaryotes - 287 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23439498..23443815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125172.2 → NP_200595.2  MIF4G domain-containing protein / MA3 domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200595.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UDA8
      Conserved Domains (2) summary
      pfam02847
      Location:613 → 725
      MA3; MA3 domain
      pfam02854
      Location:212 → 436
      MIF4G; MIF4G domain

    2. NM_180876.2 → NP_851207.1  MIF4G domain-containing protein / MA3 domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851207.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KDF4, Q8H0T8, Q8H179, Q93ZT6, Q9FJM7
      UniProtKB/TrEMBL
      A0A178UEM3, A0A5S9YFN4
      Conserved Domains (3) summary
      PHA03247
      Location:469 → 610
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:617 → 729
      MA3; MA3 domain
      pfam02854
      Location:216 → 440
      MIF4G; MIF4G domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZT6.1

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