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    WNK4 with no lysine (K) kinase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835947, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WNK4
    Official Full Name
    with no lysine (K) kinase 4
    Primary source
    TAIR:AT5G58350
    Locus tag
    AT5G58350
    See related
    Araport:AT5G58350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCK7.22; MCK7_22; with no lysine (K) kinase 4; ZIK2
    Summary
    Encodes a member of the WNK family (9 members in all) of protein kinases, the structural design of which is clearly distinct from those of other known protein kinases, such as receptor-like kinases and mitogen-activated protein kinases. Its transcription is under the control of circadian rhythms.
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    Genomic context

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    See WNK4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (23584789..23587801)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene lactate/malate dehydrogenase family protein Neighboring gene myb-like HTH transcriptional regulator family protein Neighboring gene ovate family protein 3 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compilation and characterization of a novel WNK family of protein kinases in Arabiodpsis thaliana with reference to circadian rhythms. Nakamichi N, et al. Biosci Biotechnol Biochem, 2002 Nov. PMID 12506983
    2. ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance. Campe R, et al. New Phytol, 2016 Jan. PMID 26315018
    3. Members of the Plant CRK Superfamily Are Capable of Trans- and Autophosphorylation of Tyrosine Residues. Nemoto K, et al. J Biol Chem, 2015 Jul 3. PMID 25969537, Free PMC Article
    4. Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. Nemoto K, et al. Phytochemistry, 2011 Jul. PMID 21477822
    5. High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. Koroleva OA, et al. Plant J, 2005 Jan. PMID 15610358

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125220.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    with no lysine (K) kinase 4
    NP_200643.1
    • with no lysine (K) kinase 4 (WNK4); FUNCTIONS IN: protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: with no lysine (K) kinase 5 (TAIR:AT3G51630.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23584789..23587801
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125220.4 → NP_200643.1  with no lysine (K) kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LVL5
      UniProtKB/TrEMBL
      A0A178UR28, A0A5S9YFC9, A0A654GC85
      Conserved Domains (1) summary
      cd13983
      Location:17 → 277
      STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVL5.1

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