CDKE;1 cyclin-dependent kinase E;1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CDKE;1
Official Full Name: cyclin-dependent kinase E;1
Primary source: TAIR:AT5G63610
Locus tag: AT5G63610
See related: Araport:AT5G63610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCDK8; CDKE1; cyclin-dependent kinase E;1; CYCLIN-DEPENDENT KINASE E;1; HEN3; HUA ENHANCER 3; MBK5.8; MBK5_8
Summary: significant sequence similarity to plant and animal cyclin-dependent protein kinases, and was classified as an E-type CDK with a SPTAIRE cyclin binding motif in the kinase domain.
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Genomic context

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See CDKE;1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (25463362..25465922, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYCLIN-DEPENDENT KINASE 8 positively regulates oil synthesis by activating WRINKLED1 transcription.
Title: CYCLIN-DEPENDENT KINASE 8 positively regulates oil synthesis by activating WRINKLED1 transcription.
NPR1 Promotes Its Own and Target Gene Expression in Plant Defense by Recruiting CDK8.
Title: NPR1 Promotes Its Own and Target Gene Expression in Plant Defense by Recruiting CDK8.
Findings indicate that a mutation in cyclin-dependent kinase 8 (CDK8) partially suppresses the dwarfism and constitutive resistance phenotypes of camta1/2/3.
Title: The Mediator kinase module serves as a positive regulator of salicylic acid accumulation and systemic acquired resistance.
The genetic interaction between MED5 and CDK8 was further characterized using mRNA-sequencing (RNA-seq) and metabolite analysis
Title: Mutation of Mediator subunit CDK8 counteracts the stunted growth and salicylic acid hyperaccumulation phenotypes of an Arabidopsis MED5 mutant.
sugar and the CDK8 module are capable of regulating MIR156 independently, but suggest they normally act together in a synergistic manner.
Title: Convergent repression of miR156 by sugar and the CDK8 module of Arabidopsis Mediator.
Data indicate the multiple regulatory roles of the Mediator CYCLIN-DEPENDENT KINASE8 (CDK8) module in plant defense and development.
Title: CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis.
These results place CDKE1 as a central kinase integrating diverse cellular signals and shed light on a mechanism by which plants can effectively switch between growth and stress responses. [CDKE1]
Title: Cyclin-dependent kinase E1 (CDKE1) provides a cellular switch in plants between growth and stress responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125756.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in seed oilbody biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cyclin-dependent kinase E;1

NP_201166.1

cyclin-dependent kinase E;1 (CDKE;1); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G67580.2); Has 122304 Blast hits to 120929 proteins in 4501 species: Archae - 96; Bacteria - 13482; Metazoa - 46432; Fungi - 12531; Plants - 29277; Viruses - 477; Other Eukaryotes - 20009 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

25463362..25465922 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125756.5 → NP_201166.1 cyclin-dependent kinase E;1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201166.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q70Z09, Q84TI6, Q9FFQ3

UniProtKB/TrEMBL

A0A178U8W4, A0A5S9YIW3

Conserved Domains (1) summary

cd07842
Location:24 → 333

STKc_CDK8_like; Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases