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    LIP1 Ras-related small GTP-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836603, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LIP1
    Official Full Name
    Ras-related small GTP-binding family protein
    Primary source
    TAIR:AT5G64813
    Locus tag
    AT5G64813
    See related
    Araport:AT5G64813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Light Insensitive Period1
    Summary
    The LIP1 gene encodes a small GTPase that influences the light input pathway of the plant circadian network. An MBP:LIP1 fusion protein has GTP hydrolyzing abilities in vitro. In plants, LIP1 seems to play a negative role in regulating circadian period that can be suppressed by light. LIP1 also seems to negatively affect light-pulse-dependent resetting of the clock, especially during the first portion of the subjective evening. LIP1 expression levels are not significantly affected by the circadian clock in seedlings grown under LL conditions. The levels of the YFP:LIP1 protein expressed under the control of the 35S promoter, shows a low amplitude variation, with protein levels peaking near the beginning of subjective night under LL conditions. In hypocotyl epidermal cells of dark and light-grown seedlings, a YFP:LIP1 fusion protein can be seen in the cytoplasm and the nucleus, and does not cluster in nuclear speckles. LIP1 may also be involved in photomorphogenesis.
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    Genomic context

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    See LIP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (25910015..25912900)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene CLAVATA3/ESR-RELATED 21 Neighboring gene ncRNA Neighboring gene WRKY DNA-binding protein 51 Neighboring gene thionin-like protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The circadian clock-associated small GTPase LIGHT INSENSITIVE PERIOD1 suppresses light-controlled endoreplication and affects tolerance to salt stress in Arabidopsis. Terecskei K, et al. Plant Physiol, 2013 Jan. PMID 23144185, Free PMC Article
    2. Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1. Kevei E, et al. Curr Biol, 2007 Sep 4. PMID 17683937
    3. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function of LIP1 protein causes altered cell shape.
      Title: The circadian clock-associated small GTPase LIGHT INSENSITIVE PERIOD1 suppresses light-controlled endoreplication and affects tolerance to salt stress in Arabidopsis.
    2. LIP1 plays a unique negative role in controlling circadian light input and is required for precise entrainment of the plant clock.
      Title: Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345650.1
    NM_001345651.1
    NM_125878.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related small GTP-binding family protein
    NP_001318878.1
    • Light Insensitive Period1 (LIP1); FUNCTIONS IN: GTPase activity; INVOLVED IN: circadian regulation of gene expression, photomorphogenesis; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTPase (InterPro:IPR020851), Ras (InterPro:IPR013753), RNA polymerase sigma factor 54, interaction (InterPro:IPR002078); BEST Arabidopsis thaliana protein match is: Ras-related small GTP-binding family protein (TAIR:AT5G09910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25910015..25912900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345650.1 → NP_001318878.1  Ras-related small GTP-binding family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5J9, Q9LV96
      UniProtKB/TrEMBL
      A0A178UH00, A0A5S9YH21, A0A654GE54
      Conserved Domains (1) summary
      PLN00023
      Location:2 → 342
      PLN00023; GTP-binding protein; Provisional

    2. NM_001345651.1 → NP_001331706.1  Ras-related small GTP-binding family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5J9, Q9LV96
      UniProtKB/TrEMBL
      A0A178UH00, A0A5S9YH21, A0A654GE54
      Conserved Domains (1) summary
      PLN00023
      Location:2 → 342
      PLN00023; GTP-binding protein; Provisional

    3. NM_125878.3 → NP_568996.1  Ras-related small GTP-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5J9, Q9LV96
      UniProtKB/TrEMBL
      A0A178UH00, A0A5S9YH21, A0A654GE54
      Conserved Domains (1) summary
      PLN00023
      Location:2 → 342
      PLN00023; GTP-binding protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5J9.1

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